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Ferritin light-chain subunits: key elements for the electron transfer across the protein cage

Chem Commun (Camb). 2014 Dec 18;50(97):15358-61. doi: 10.1039/c4cc07996e. Epub 2014 Oct 28.

Abstract

The first specific functionality of the light-chain (L-chain) subunit of the universal iron storage protein ferritin was identified. The electrons released during iron-oxidation were transported across the ferritin cage specifically through the L-chains and the inverted electron transport through the L-chains also accelerated the demineralization of ferritin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoferritins / chemistry*
  • Apoferritins / metabolism
  • Cytochromes c / chemistry
  • Cytochromes c / metabolism
  • Electron Transport
  • Horses
  • Humans
  • Iron / chemistry
  • Oxidation-Reduction
  • Protein Subunits / chemistry*
  • Protein Subunits / metabolism

Substances

  • Protein Subunits
  • Cytochromes c
  • Apoferritins
  • Iron