PIGS: automatic prediction of antibody structures

Bioinformatics. 2008 Sep 1;24(17):1953-4. doi: 10.1093/bioinformatics/btn341. Epub 2008 Jul 19.

Authors

Paolo Marcatili¹, Alessandra Rosi, Anna Tramontano

Affiliation

¹ Department of Biochemical Sciences and Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy.

PMID: 18641403
DOI: 10.1093/bioinformatics/btn341

Abstract

We describe a web server for the automatic prediction of immunoglobulin variable domains based on the canonical structure model. The server is user-friendly and flexible. It allows the user to select the templates for the frameworks and the loops using different strategies. The final output is a full-fledged 3D model of the variable domains of the target immunoglobulin.

Availability: The server is openly accessible to academic users at the address: http://arianna.bio.uniroma1.it/pigs. It does not require registration and there is no limit to the number of sequences that can be submitted.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Amino Acid Sequence
Antibodies / chemistry*
Antibodies / ultrastructure*
Computer Simulation
Immunoglobulin Variable Region / chemistry*
Immunoglobulin Variable Region / ultrastructure*
Internet
Models, Chemical*
Models, Molecular*
Molecular Sequence Data
Protein Conformation
Protein Structure, Tertiary
Sequence Analysis, Protein / methods
Software*
User-Computer Interface

Substances

Antibodies
Immunoglobulin Variable Region