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f2.S coagulation factor II, thrombin S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 446352, updated on 9-Dec-2024

Summary

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Official Symbol
f2.S
Official Full Name
coagulation factor II, thrombin S homeolog
Primary source
Xenbase:XB-GENE-17331609
Locus tag
XELAEV_18024485mg
See related
EnsemblRapid:ENSXLAG00005020503 AllianceGenome:Xenbase:XB-GENE-17331609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
lpa
Summary
Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to act upstream of or within several processes, including acute-phase response; platelet activation; and positive regulation of blood coagulation. Predicted to be located in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See f2.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
14
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (14795370..14810972)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (14200037..14215724)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 1 S homeolog Neighboring gene zinc finger protein 408 S homeolog Neighboring gene cytoskeleton-associated protein 5-A-like Neighboring gene small nucleolar RNA SNORD67 Neighboring gene small nucleolar RNA SNORD67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82169

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acute-phase response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coagulation factor II, thrombin S homeolog
Names
coagulation factor 2 (thrombin) S homeolog
lipoprotein, Lp(a)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093048.1 → NP_001086517.1  coagulation factor II, thrombin S homeolog precursor

    See identical proteins and their annotated locations for NP_001086517.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076742
    UniProtKB/TrEMBL
    A0A974HKZ8, Q6DFJ5, Q6GNK4
    Related
    ENSXLAP00005060080.1, ENSXLAT00005061529.1
    Conserved Domains (5) summary
    smart00020
    Location:348 → 596
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:23 → 86
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:107 → 185
    KR; Kringle domain
    cd00190
    Location:349 → 600
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:301 → 348
    Thrombin_light; Thrombin light chain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    14795370..14810972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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