Methylation analysis articles from across Nature Portfolio

Using data from a cohort of patients (n = 346) with lung adenocarcinoma and from multiple independent cohorts, DNA methylation signatures were evaluated to build and validate an accurate model predicting the development of brain metastasis.

At single-cell resolution, Tarkhov et al. delineate stochastic and co-regulated components of epigenetic aging, revealing a simultaneous loss of regulation at the epigenetic and transcriptional levels in aging.

Here the authors develop a method to quantify all combinations of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine at individual CpG dyads, including in single cells, to identify the relationship between the local 5mC density, histone marks and maintenance methylation fidelity.

A metagenomic approach to identifying the sources of N⁶-methyldeoxyadenine (6mA) in eukaryotic DNA found no evidence of high 6mA abundances in sampled eukaryotes.