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Biophysics is the study of physical phenomena and physical processes in living things, on scales spanning molecules, cells, tissues and organisms. Biophysicists use the principles and methods of physics to understand biological systems. It is an interdisciplinary science, closely related to quantitative and systems biology.
Spring-like force sensors bioprinted in the developing neural tube of growing chick embryos enable the measurement of forces generated by embryonic tissues with micrometre-level resolution.
The cell cortex consists of a chemical and a mechanical subsystem, but how energy is allocated between them is unknown. Now, measurements of the entropy production rate have revealed what determines the cell cortex’s energy budget.
This study shows that liquid-liquid phase separation enhances the catalytic efficiency of peptides by up to 15,000-fold through the formation of peptide coacervates. These microreactors can also selectively recruit phosphorylated proteins, providing insights into the evolution of enzymatic activity.
CryoSTAR is a deep neural network model that resolves continuous conformational heterogeneity from cryo-EM datasets using an initial atomic model as the reference to generate both density maps and reasonable coarse-grained models for different conformations.
This study introduces an in vivo protein footprinting method, revealing structural changes in proteome during progressing AD. It demonstrates these changes occur before expression alterations, advancing understanding of protein misfolding mechanisms.
A histidine-to-asparagine exchange and a small-sidechain residue at the i-4 position of the chlorophyll a403/a603 binding sites are responsible for the red-shifted light adaption of the light harvesting complexes from Trachydiscus minutus and other eukaryotic algae.
Spring-like force sensors bioprinted in the developing neural tube of growing chick embryos enable the measurement of forces generated by embryonic tissues with micrometre-level resolution.
The cell cortex consists of a chemical and a mechanical subsystem, but how energy is allocated between them is unknown. Now, measurements of the entropy production rate have revealed what determines the cell cortex’s energy budget.
GBP1 is an important innate immunity component that contributes to the control of cytosol-invasive bacterial pathogens. Using cryo-electron microscopy (cryo-EM), cryo-electron tomography (cryo-ET) and biophysical assays, we show how GBP1 oligomers enwrap and remodel the lipopolysaccharide (LPS)-containing membrane of gram-negative bacterial pathogens.
A deep learning algorithm is presented to classify single-particle tracking trajectories into theoretical models of anomalous diffusion and detect if the trajectory is related to a model not originally found within the training dataset.
