Extended Data Fig. 9: Cellular interactions within the suture niche.

a. Dotplot of gene expression of receptor-ligands related to angiogenesis in IM and EC clusters. b. NicheNet predictions of differentially enriched cell-cell interaction pairs between endothelial tip cells and osteolineage cells in the IM pathway, compared to the EC pathway. c. CellphoneDB predictions of Ligand-receptor pairs between endothelial tip cells and cells of the osteogenic lineage. d. NicheNet inferred differential cell-cell interactions between osteogenic cell states and Tip cells in the EC and IM niches. e. Schematic of endothelial and osteogenic cell state interactions at the boundaries of the suture mesenchyme. f. Enrichment of axonogenesis gene set from the Gene-ontology 2023 database across the organ-axis spatial bins.