| Patrick Stewart | ... Prof. Charles Xavier |
| Hugh Jackman | ... Logan -- Wolverine |
| Ian McKellen | ... Eric Lensherr -- Magneto |
| Halle Berry | ... Ororo Munroe -- Storm |
| Famke Janssen | ... Jean Grey |
| James Marsden | ... Scott Summers -- Cyclops |
| Rebecca Romijn | ... Raven Darkholme -- Mystique |
| Brian Cox | ... William Stryker |
| Alan Cumming | ... Kurt Wagner -- Nightcrawler |
| Bruce Davison | ... Sen. Kelly |
| Shawn Ashmore | ... Bobby Drake -- Ice Man |
| Aaron Stanford | ... John Allerdyce -- Pyro |
| Kelly Hu | ... Yuriko Oyama -- Deathstrike |
|
| and |
| Anna Paquin | ... Marie -- Rogue |
|
| Katie Stuart | ... Kitty Pryde -- Shadowcat |
| Kea Wong | ... Jubilation Lee -- Jubilee |
| Cotter Smith | ... President McKenna |
|
| In order of appearance |
| Chiara Zanni | ... White House Tour Guide |
| Jackie A. Greenbank | ... President's Secretary |
| Michael Soltis | ... White House Checkpoint Agent |
| Michael David Simms | ... White House Agent (Lead Agent) |
| David Fabrizio | ... Oval Office Agent Fabrizio |
| Roger R. Cross | ... Oval Office Agent Cartwright |
| Richard Bradshaw | ... Special Ops Agent |
| Bryce Hodgson | ... Artie |
| Glen Curtis | ... Museum Teenager #1 |
| Greg Rikaart | ... Museum Teenager #2 |
| Shauna Kain | ... Theresa Cassidy -- Siryn |
| Ty Olsson | ... Mitchell Laurio |
| Alfonso Quijada | ... Federal Bldg. Cleaning Twin #1 |
| Rene Quijada | ... Federal Bldg. Cleaning Twin #2 |
| Brad Loree | ... Stryker at Age 40 |
| Sheri G. Feldman | ... Augmentation Room Doctor |
| Connor Widdows | ... Jones |
| Daniel Cudmore | ... Piotr Rasputin -- Colossus |
| Peter Wingfield | ... Stryker Soldier Lyman |
| Charles Siegel | ... Dr. Shaw |
| Steve Bacic | ... Dr. Hank McCoy |
| Rebecca Romijn | ... Grace |
| Michael Reid MacKay | ... Jason 143 |
| James Kirk | ... Ronny Drake |
| Jill Teed | ... Madeline Drake |
| Alfred E. Humphreys | ... William Drake |
| Michasha Armstrong | ... Plastic Prison Guard |
| Robert Hayley | ... Cop |
| Mark Lukyn | ... Cop #1 (Lead Cop) |
| Kendall Cross | ... Cop #2 |
| Lori Stewart | ... F-16 Fighter Pilot |
| Keely Purvis | ... Little Girl 143 |
| Dylan Kussman | ... Stryker Soldier Wilkins |
| Jason S. Whitmer | ... Stryker Soldier Smith |
| Aaron Pearl | ... Stryker Soldier |
| Aaron Douglas | ... Stryker Soldier |
| Colin Lawrence | ... Stryker Soldier |
| Richard C. Burton | ... Stryker Soldier |
| Michael Joycelyn | ... Stryker Soldier |
| Nolan Funk | ... X-Kid (Captured) |
| Devin Douglas Drewitz | ... X-Kid (Captured) |
| Jermaine Lopez | ... X-Kid (Captured) |
| Sideah Alladice | ... X-Kid (Captured) |
| Kurt Max Runte | ... Chief of Staff Abrahams |
| Benjamin Glenday | ... Cameraman |
| Ted Friend | ... News Reporter |
| Mi-Jung Lee | ... News Reporter |
| Marrett Green | ... News Reporter |
| Jill Krop | ... News Reporter |
| Brian Peck | ... News Reporter |