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ENTRY	nt06167
Name	Human cytomegalovirus (HCMV)
Category	Disease view; Viral infection
Pathway	hsa05163 Human cytomegalovirus infection
Genome	T40080
Disease	H00368 Cytomegalovirus infection
Display	drug-target relation   disease type

ERK signaling N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00392    UL55 → EGFR N00386    UL55 → PDGFR → GRB2 → SOS → RAS → RAF → MEK → ERK   PI3K signaling N00039    PDGF → PDGFR → PI3K → PIP3 → AKT → MTOR → S6K N00385    UL55 → PDGFRA N00387        (IE1-72,IE2-86) → PI3K N00582    IGF1 → IGF1R → PI3K → PIP3 → AKT ⊣ (TSC1+TSC2) ⊣ RHEB → MTOR ⊣ EIF4EBP1 N00388                    UL38 ⊣ (TSC1+TSC2) N00390    EGF → EGFR → PI3K → PIP3 → AKT → IKK → NFKBIA → NFKB N00391    UL55 → EGFR   JAK-STAT signaling N00415    (IL10,IL19,IL20,IL.. → ((IL10RB+(IL10RA,I.. → (JAK1+TYK2) → STAT3 N00416    vIL10 → IL10R → JAK1 → STAT3   CGAS-STING signaling N00395    DNA → CGAS → cGAMP → STING1 → TBK1 → IRF3 ⇒ (IFNA,IFNB) N00396            UL82 ⊣ STING1   TNF signaling N00151    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB N00397            UL26 ⊣ IKK N00398                    IE2-86 ⊣ NFKB N00389                    IE1-72 ⇒ NFKB   Chemokine signaling N00401        CXCL12 → CXCR4 → GNAQ → (PLCB,PLCG) → IP3 → Ca2+ → CALM = CN → NFAT N00402            US28 → GNAQ N00407            UL33 → (GNAQ,GNA11) N00410        DA → DRD1 → GNAS → ADCY5 → cAMP → PKA → CREB N00411            UL33 → GNAS N00403        CX3CL1 → CX3CR1 → GNAI ⊣ ADCY → cAMP → PKA N00404            US28 → (GNAI,GNAO) N00412            UL33 → (GNAI,GNAO) N00405        CXCL12 → CXCR4 → GNA12/13 → (ARHGEF12,ARHGEF1) → RHOA → ROCK1/2 N00406        (CCL2/3/4/5,CX3CL1.. → US28 → GNA12/13 N00408        LPA → LPAR → GNB/G → RHOA N00409            UL33 → GNB/G N00399        CCL2 → CCR2 → GNB/G → PI3K → PIP3 → AKT → IKK → NFKBIA → NFKB N00400            US28 → GNB/G N00154        CXCL8 → CXCR2 → GNB/G → PI3Kgamma → PIP3 → AKT → MTOR N00427        vCXCL1 → CXCR2 N00413        CXCL12 → CXCR4 → GNB/G → PLCB → (Ca2+,DAG) → PKC → PTK2B → (PTK2+BCAR1+CRK+PX.. N00414                    US27 → Ca2+ → PKC N00428        CCL5 → CCR5 → GNB/G → PLCB → (Ca2+,DAG) → PKC N00429    UL22A ⊣ CCL5   MHC presentation N00363        TAP1/2 = TAPBP = (PDIA3+CALR) → (MHCI+B2M) N00417    US6 ⊣ TAP1/2 N00418                (US2,US11) ⊣ MHCI N00419                (US3,US10) ⊣ MHCI   Cell cycle N00066    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00420        IE2-86 ⊣ TP53 N00421            IE2-86 ⊣ CDKN1A N00422                    IE2-86 → RB1 ⌿ E2F N00423                    IE1-72 → RB1 ⌿ E2F N00424                    UL82 → RB1 ⌿ E2F   Apoptosis N00146    (FASLG,TNFSF10) → (FAS,TNFRSF10B) → FADD → (CASP8,CASP10) → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00425            UL36 ⊣ CASP8 N00426                    UL37x1 ⊣ BAX   Cytoskeletal regulation N00393    FN1 → (ITGA+ITGB) → SRC → ARHGAP35 ⊣ RHOA N00394    UL75 → (ITGAV+ITGB3) → SRC → RAC ⊣ RHOA