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Homo sapiens (human): 7915
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Entry
7915 CDS
T01001
Symbol
ALDH5A1, SSADH, SSDH
Name
(RefSeq) aldehyde dehydrogenase 5 family member A1
KO
K00139
succinate-semialdehyde dehydrogenase [EC:
1.2.1.24
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00250
Alanine, aspartate and glutamate metabolism
hsa00650
Butanoate metabolism
hsa01100
Metabolic pathways
Module
hsa_M00027
GABA (gamma-Aminobutyrate) shunt
Disease
H00835
Succinic semialdehyde dehydrogenase deficiency
Drug target
Valproic acid (
DG00849
):
D00304
<US>
D00399
<US>
D00710
<JP/US>
D08667
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00650 Butanoate metabolism
7915 (ALDH5A1)
09105 Amino acid metabolism
00250 Alanine, aspartate and glutamate metabolism
7915 (ALDH5A1)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.1 With NAD+ or NADP+ as acceptor
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
7915 (ALDH5A1)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Aldedh
Motif
Other DBs
NCBI-GeneID:
7915
NCBI-ProteinID:
NP_001071
OMIM:
610045
HGNC:
408
Ensembl:
ENSG00000112294
UniProt:
P51649
X5DQN2
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:24494969..24537207
Genome browser
AA seq
535 aa
AA seq
DB search
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV
KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF
AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF
EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR
VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
NT seq
1608 nt
NT seq
+upstream
nt +downstream
nt
atggcgacctgcatttggctgcggagctgtggggcccggcgcctcgggtcgacgtttcca
ggctgccgcctccgcccccgcgccggcggcctggtccctgcctccgggcctgcgcccggc
ccggcccagctccgctgctacgctgggcgcctggcgggcctctctgcggcgctgctgcgc
accgacagcttcgtgggcggccgctggctcccggccgccgccaccttccccgtgcaagac
ccggccagcggcgccgctctgggcatggtagccgactgcggggtgcgagaggcccgcgcc
gccgtgcgcgctgcctacgaggctttctgccgctggagggaggtctccgccaaggagagg
agttcattacttcggaagtggtacaatttaatgatacaaaataaggatgaccttgccaga
ataatcacagctgaaagtggaaagccactgaaggaggcacatggagaaattctctattcc
gcctttttcctagagtggttctctgaggaagcccgccgtgtttacggagacattatccac
accccggcaaaggacaggcgggccctggtcctcaagcagcccataggcgtggctgcagtc
atcaccccgtggaatttccccagtgccatgatcacccggaaggtgggggccgccctggca
gccggctgtactgtcgtggtgaagcctgccgaagacacgcccttctccgccctggccctg
gctgagcttgcaagccaggctgggattccttcaggtgtatacaatgttattccctgttct
cgaaagaatgccaaggaagtaggggaggcaatttgtactgatcctctggtgtccaaaatt
tcctttactggttcaacaactacaggaaagatcctgttgcaccacgcagcaaactctgtg
aaaagggtctctatggagctgggcggccttgctccatttatagtatttgacagtgccaac
gtggaccaggctgtagcaggggccatggcatctaaatttaggaacactggacagacttgt
gtttgctcaaaccaattcttggtgcaaaggggcatccatgatgcctttgtaaaagcattc
gccgaggccatgaagaagaacctgcgcgtaggtaatggatttgaggaaggaactactcag
ggcccattaattaatgaaaaagcggtagaaaaggtggagaaacaggtgaatgatgccgtt
tctaaaggtgccaccgttgtgacaggtggaaaacgacaccaacttggaaaaaatttcttt
gagcctaccctgctgtgcaatgtcacccaggacatgctgtgcactcatgaagagactttc
gggcctctggcaccagttatcaagttcgatacagaggaggaggctatagcaatcgctaac
gcagctgatgttgggttagcaggttatttttactctcaagacccagcccagatctggaga
gtggcagagcagctggaagtgggcatggttggcgtcaacgaaggattaatttcctctgtg
gagtgcccttttggtggagtgaagcagtccggccttgggcgagaggggtccaagtatggc
attgatgagtatctggaactcaagtatgtgtgttacgggggcttgtag
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integrated database retrieval system