| Entry |
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| Symbol |
GART, AIRS, GARS, GARTF, PAIS, PGFT, PRGS
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| Name |
(RefSeq) phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
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| KO |
| K11787 | phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1] |
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| Organism |
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| Pathway |
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| Module |
| hsa_M00048 | De novo purine biosynthesis, PRPP + glutamine => IMP |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
2618 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
2618 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
2618 (GART)
Enzymes [BR:hsa01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
2618 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
2618 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
2618 (GART)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
21:complement(33503931..33542893)
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| AA seq |
1010 aa
MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQ
FCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIP
TAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAF
GAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAP
QVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAIKFEGAIYRKD
VGFRAIAFLQQPRSLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEG
HLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKN
LIESMQINGSVLKNGSLTNHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIV
ISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILS
GPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE |
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| NT seq |
3033 nt +upstreamnt +downstreamnt
atggcagcccgagtacttataattggcagtggaggaagggaacatacgctggcctggaaa
cttgcacagtctcatcatgtcaaacaagtgttggttgccccaggaaacgcaggcactgcc
tgctctgaaaagatttcaaataccgccatctcaatcagtgaccacactgcccttgctcaa
ttctgcaaagagaagaaaattgaatttgtagttgttggaccagaagcacctctggctgct
gggattgttgggaacctgaggtctgcaggagtgcaatgctttggcccaacagcagaagcg
gctcagttagagtccagcaaaaggtttgccaaagagtttatggacagacatggaatccca
accgcacaatggaaggctttcaccaaacctgaagaagcctgcagcttcattttgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctggaaaaggggtgattgtt
gcaaagagcaaagaagaggcctgcaaagctgtacaagagatcatgcaggagaaagccttt
ggggcagctggagaaacaattgtcattgaagaacttcttgacggagaagaggtgtcgtgt
ctgtgtttcactgatggcaagactgtggcccccatgcccccagcacaggaccataagcga
ttactggagggagatggtggccctaacacagggggaatgggagcctattgtccagcccct
caggtttctaatgatctattactaaaaattaaagatactgttcttcagaggacagtggat
ggcatgcagcaagagggtactccatatacaggtattctctatgctggaataatgctgacc
aagaatggcccaaaagttctagagtttaattgccgttttggtgatccagagtgccaagta
atcctcccacttcttaaaagtgatctttatgaagtgattcagtccaccttagatggactg
ctctgcacatctctgcctgtttggctagaaaaccacaccgccctaactgttgtcatggca
agtaaaggttatcctggagactacaccaagggtgtagagataacagggtttcctgaggct
caagctctaggactggaggtgttccatgcaggcactgccctcaaaaatggcaaagtagta
actcatgggggtagagttcttgcagtcacagccatccgggaaaatctcatatcagccctt
gaggaagccaagaaaggactagctgctataaagtttgagggagcaatttataggaaagac
gtcggctttcgtgccatagctttcctccagcagcccaggagtttgacttacaaggaatct
ggagtagatatcgcagctggaaatatgctggtcaagaaaattcagcctttagcaaaagcc
acttccagatcaggctgtaaagttgatcttggaggttttgctggtctttttgatttaaaa
gcagctggtttcaaagatccccttctggcctctggaacagatggcgttggaactaaacta
aagattgcccagctatgcaataaacatgataccattggtcaagatttggtagcaatgtgt
gttaatgatattctggcacaaggagcagagcccctcttcttccttgattacttttcctgt
ggaaaacttgacctcagtgtaactgaagctgttgttgctggaattgctaaagcttgtgga
aaagctggatgtgctctccttggaggtgaaacagcagaaatgcctgacatgtatccccct
ggagagtatgacctagctgggtttgccgttggtgccatggagcgagatcagaaactccct
cacctggaaagaatcactgagggtgatgttgttgttggaatagcttcatctggtcttcat
agcaatggatttagccttgtgaggaaaatcgtggcaaaatcttccctccagtactcctct
ccagcacctgatggttgtggtgaccagactttaggggacttacttctcacgcctaccaga
atctacagccattcactgttacctgtcctacgttcaggacatgtcaaagcctttgcccat
attactggtggaggattactagagaacatccccagagtcctccctgagaaacttggggta
gatttagatgcccagacctggaggatccccagggtcttctcatggttgcagcaggaagga
cacctctctgaggaagagatggccagaacatttaactgtggggttggcgctgtccttgtg
gtatcaaaggagcagacagagcagattctgagggatatccagcagcacaaggaagaagcc
tgggtgattggcagtgtggttgcacgagctgaaggttccccacgtgtgaaagtcaagaat
ctgattgaaagcatgcaaataaatgggtcagtgttgaagaatggctccctgacaaatcat
ttctcttttgaaaaaaaaaaggccagagtggctgtcttaatatctggaacaggatcgaac
ctgcaagcacttatagacagtactcgggaaccaaatagctctgcacaaattgatattgtt
atctccaacaaagccgcagtagctgggttagataaagcggaaagagctggtattcccact
agagtaattaatcataaactgtataaaaatcgtgtagaatttgacagtgcaattgaccta
gtccttgaagagttctccatagacatagtctgtcttgcaggattcatgagaattctttct
ggcccctttgtccaaaagtggaatggaaaaatgctcaatatccacccatccttgctccct
tcttttaagggttcaaatgcccatgagcaagccctggaaaccggagtcacagttactggg
tgcactgtacactttgtagctgaagatgtggatgctggacagattattttgcaagaagct
gttcccgtgaagaggggtgatactgtcgcaactctttctgaaagagtaaaattagcagaa
cataaaatatttcctgcagcccttcagctggtggccagtggaactgtacagcttggagaa
aatggcaagatctgttgggttaaagaggaatga |
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