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KEGG   Homo sapiens (human): 1846
Entry
1846              CDS       T01001                                 
Symbol
DUSP4, HVH2, MKP-2, MKP2, TYP
Name
(RefSeq) dual specificity phosphatase 4
  KO
K04459  dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04148  Efferocytosis
Network
nt06526  MAPK signaling
nt06535  Efferocytosis
  Element
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
N01774  ERK-DUSP4 negative feedback pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1846 (DUSP4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    1846 (DUSP4)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     1846 (DUSP4)
    3.1.3.48  protein-tyrosine-phosphatase
     1846 (DUSP4)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   MAPK phosphatases
    1846 (DUSP4)
SSDB
Motif
Pfam: DSPc Rhodanese Y_phosphatase PTP-SAK Tc-R-P PTP-NADK CDKN3 PTPlike_phytase
Other DBs
NCBI-GeneID: 1846
NCBI-ProteinID: NP_001385
OMIM: 602747
HGNC: 3070
Ensembl: ENSG00000120875
UniProt: Q13115
Structure
LinkDB
Position
8:complement(29333064..29350684)
AA seq 394 aa
MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY
ILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLRE
DSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLD
LGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHY
QYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKR
VRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATP
TSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC
NT seq 1185 nt   +upstreamnt  +downstreamnt
atggtgacgatggaggagctgcgggagatggactgcagtgtgctcaaaaggctgatgaac
cgggacgagaatggcggcggcgcgggcggcagcggcagccacggcaccctggggctgccg
agcggcggcaagtgcctgctgctggactgcagaccgttcctggcgcacagcgcgggctac
atcctaggttcggtcaacgtgcgctgtaacaccatcgtgcggcggcgggctaagggctcc
gtgagcctggagcagatcctgcccgccgaggaggaggtacgcgcccgcttgcgctccggc
ctctactcggcggtcatcgtctacgacgagcgcagcccgcgcgccgagagcctccgcgag
gacagcaccgtgtcgctggtggtgcaggcgctgcgccgcaacgccgagcgcaccgacatc
tgcctgctcaaaggcggctatgagaggttttcctccgagtacccagaattctgttctaaa
accaaggccctggcagccatcccacccccggttccccccagtgccacagagcccttggac
ctgggctgcagctcctgtgggaccccactacacgaccaggggggtcctgtggagatcctt
cccttcctctacctcggcagtgcctaccatgctgcccggagagacatgctggacgccctg
ggcatcacggctctgttgaatgtctcctcggactgcccaaaccactttgaaggacactat
cagtacaagtgcatcccagtggaagataaccacaaggccgacatcagctcctggttcatg
gaagccatagagtacatcgatgccgtgaaggactgccgtgggcgcgtgctggtgcactgc
caggcgggcatctcgcggtcggccaccatctgcctggcctacctgatgatgaagaaacgg
gtgaggctggaggaggccttcgagttcgttaagcagcgccgcagcatcatctcgcccaac
ttcagcttcatggggcagctgctgcagttcgagtcccaggtgctggccacgtcctgtgct
gcggaggctgctagcccctcgggacccctgcgggagcggggcaagacccccgccaccccc
acctcgcagttcgtcttcagctttccggtctccgtgggcgtgcactcggcccccagcagc
ctgccctacctgcacagccccatcaccacctctcccagctgttag

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