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Homo sapiens (human): 1021
Help
Entry
1021 CDS
T01001
Symbol
CDK6, MCPH12, PLSTIRE
Name
(RefSeq) cyclin dependent kinase 6
KO
K02091
cyclin-dependent kinase 6 [EC:
2.7.11.22
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04110
Cell cycle
hsa04115
p53 signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04218
Cellular senescence
hsa04934
Cushing syndrome
hsa05160
Hepatitis C
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05206
MicroRNAs in cancer
hsa05212
Pancreatic cancer
hsa05214
Glioma
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06170
Influenza A virus (IAV)
nt06230
Cell cycle (cancer)
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06265
Bladder cancer
nt06266
Non-small cell lung cancer
nt06267
Small cell lung cancer
nt06268
Melanoma
nt06270
Breast cancer
nt06273
Glioma
nt06276
Chronic myeloid leukemia
Element
N00066
MDM2-p21-Cell cycle G1/S
N00067
Deleted p14(ARF) to p21-cell cycle G1/S
N00068
Amplified MDM2 to p21-cell cycle G1/S
N00069
p16-Cell cycle G1/S
N00070
Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071
Deleted p16(INK4a) to p16-cell cycle G1/S
N00076
Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00088
Amplified MYC to p15-cell cycle G1/S
N00089
Amplified MYC to cell cycle G1/S
N00090
p15-Cell cycle G1/S
N00168
KSHV vCyclin to cell cycle G1/S
N00347
p300-p21-Cell cycle G1/S
N00483
EBV EBNA3C to cell cycle G1/S
Disease
H00269
Primary microcephaly
Drug target
Abemaciclib:
D10688
<JP/US>
Alvocidib (
DG02041
):
D02880
D09868
Atirmociclib:
D12834
Lerociclib:
D11455
Palbociclib (
DG01831
):
D10372
<JP/US>
D10652
Ribociclib (
DG02084
):
D10883
D10979
<US>
Trilaciclib (
DG03146
):
D11130
D11987
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
1021 (CDK6)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1021 (CDK6)
05206 MicroRNAs in cancer
1021 (CDK6)
05203 Viral carcinogenesis
1021 (CDK6)
09162 Cancer: specific types
05212 Pancreatic cancer
1021 (CDK6)
05225 Hepatocellular carcinoma
1021 (CDK6)
05214 Glioma
1021 (CDK6)
05220 Chronic myeloid leukemia
1021 (CDK6)
05218 Melanoma
1021 (CDK6)
05224 Breast cancer
1021 (CDK6)
05222 Small cell lung cancer
1021 (CDK6)
05223 Non-small cell lung cancer
1021 (CDK6)
09172 Infectious disease: viral
05160 Hepatitis C
1021 (CDK6)
05164 Influenza A
1021 (CDK6)
05162 Measles
1021 (CDK6)
05163 Human cytomegalovirus infection
1021 (CDK6)
05167 Kaposi sarcoma-associated herpesvirus infection
1021 (CDK6)
05169 Epstein-Barr virus infection
1021 (CDK6)
05165 Human papillomavirus infection
1021 (CDK6)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
1021 (CDK6)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
1021 (CDK6)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.22 cyclin-dependent kinase
1021 (CDK6)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: CMGC group
CDK family
1021 (CDK6)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Kdo
APH
Haspin_kinase
RIO1
Kinase-like
FTA2
Uricase
Motif
Other DBs
NCBI-GeneID:
1021
NCBI-ProteinID:
NP_001138778
OMIM:
603368
HGNC:
1777
Ensembl:
ENSG00000105810
UniProt:
Q00534
Structure
PDB
PDBj
LinkDB
All DBs
Position
7:complement(92604921..92836573)
Genome browser
AA seq
326 aa
AA seq
DB search
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
NT seq
981 nt
NT seq
+upstream
nt +downstream
nt
atggagaaggacggcctgtgccgcgctgaccagcagtacgaatgcgtggcggagatcggg
gagggcgcctatgggaaggtgttcaaggcccgcgacttgaagaacggaggccgtttcgtg
gcgttgaagcgcgtgcgggtgcagaccggcgaggagggcatgccgctctccaccatccgc
gaggtggcggtgctgaggcacctggagaccttcgagcaccccaacgtggtcaggttgttt
gatgtgtgcacagtgtcacgaacagacagagaaaccaaactaactttagtgtttgaacat
gtcgatcaagacttgaccacttacttggataaagttccagagcctggagtgcccactgaa
accataaaggatatgatgtttcagcttctccgaggtctggactttcttcattcacaccga
gtagtgcatcgcgatctaaaaccacagaacattctggtgaccagcagcggacaaataaaa
ctcgctgacttcggccttgcccgcatctatagtttccagatggctctaacctcagtggtc
gtcacgctgtggtacagagcacccgaagtcttgctccagtccagctacgccacccccgtg
gatctctggagtgttggctgcatatttgcagaaatgtttcgtagaaagcctctttttcgt
ggaagttcagatgttgatcaactaggaaaaatcttggacgtgattggactcccaggagaa
gaagactggcctagagatgttgcccttcccaggcaggcttttcattcaaaatctgcccaa
ccaattgagaagtttgtaacagatatcgatgaactaggcaaagacctacttctgaagtgt
ttgacatttaacccagccaaaagaatatctgcctacagtgccctgtctcacccatacttc
caggacctggaaaggtgcaaagaaaacctggattcccacctgccgcccagccagaacacc
tcggagctgaatacagcctga
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integrated database retrieval system