KEGG REACTION: R03875

REACTION: R03875

Entry

R03875                      Reaction

Definition

Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine

Equation

C02188 + C00019 <=> C05544 + C00021

Reaction class

RC00003

C00019_C00021

RC00060

C02188_C05544

Enzyme

2.1.1.59        2.1.1.60        2.1.1.354       2.1.1.355
2.1.1.356       2.1.1.357       2.1.1.359       2.1.1.360
2.1.1.361       2.1.1.364       2.1.1.367       2.1.1.368
2.1.1.369       2.1.1.370       2.1.1.371       2.1.1.372

Pathway

rn00310

Lysine degradation

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.59
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.60
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.354
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.355
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.356
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.357
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.359
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.360
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.361
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.364
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.367
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.368
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.369
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.370
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.371
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine
    2.1.1.372
     R03875  Protein lysine + S-Adenosyl-L-methionine <=> Protein N6-methyl-L-lysine + S-Adenosyl-L-homocysteine

Orthology

K04462

[histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]

K06101

[histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]

K09186

[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]

K09187

[histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]

K09188

[histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]

K09189