Entry Name Scrapie conformation PrPSc to VGCC-Ca2+ -apoptotic pathway
Definition PRNP* -| VGCC(N,L-type) -> Ca2+
Expanded 5621v1 -| (774,775,776,778,779) -> C00076
Class Type Variant
Pathway Disease Gene 774 CACNA1B; calcium voltage-gated channel subunit alpha1 B
775 CACNA1C; calcium voltage-gated channel subunit alpha1 C
776 CACNA1D; calcium voltage-gated channel subunit alpha1 D
778 CACNA1F; calcium voltage-gated channel subunit alpha1 F
779 CACNA1S; calcium voltage-gated channel subunit alpha1 S
Variant 5621v1 (PRNP*) PRNP scrapie conformation
Metabolite Reference Authors Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
Title The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
Journal Reference Authors Thellung S, Florio T, Villa V, Corsaro A, Arena S, Amico C, Robello M, Salmona M, Forloni G, Bugiani O, Tagliavini F, Schettini G
Title Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126.
Journal Reference Authors Sandberg MK, Wallen P, Wikstrom MA, Kristensson K
Title Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Ca(v) 2.2) which is ameliorated by quinacrine treatment.
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