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KEGG   NETWORK: N01751
Entry
N01751                      Network                                
Name
Macrophage EPO signaling
Definition
EPO -> EPOR -> JAK2 -> ERK -> CEBPB => PPARG+RXR => MERTK,GAS6,MFGE8,CD36
  Expanded
2056 -> 2057 -> 3717 -> 5594,5595 -> 1051 => 5468+6256 => 10461,2621,4240,948
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148  Efferocytosis
Gene
2056  EPO; erythropoietin
2057  EPOR; erythropoietin receptor
3717  JAK2; Janus kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
1051  CEBPB; CCAAT enhancer binding protein beta
5468  PPARG; peroxisome proliferator activated receptor gamma
6256  RXRA; retinoid X receptor alpha
10461  MERTK; MER proto-oncogene, tyrosine kinase
2621  GAS6; growth arrest specific 6
4240  MFGE8; milk fat globule EGF and factor V/VIII domain containing
948  CD36; CD36 molecule
Reference
  Authors
Luo B, Gan W, Liu Z, Shen Z, Wang J, Shi R, Liu Y, Liu Y, Jiang M, Zhang Z, Wu Y
  Title
Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance.
  Journal
Immunity 44:287-302 (2016)
DOI:10.1016/j.immuni.2016.01.002
Reference
  Authors
Peng B, Kong G, Yang C, Ming Y
  Title
Erythropoietin and its derivatives: from tissue protection to immune regulation.
  Journal
Cell Death Dis 11:79 (2020)
DOI:10.1038/s41419-020-2276-8
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