KEGG NETWORK: N01494

NETWORK: N01494

Entry

N01494                      Network

Name

Alternative pathway of complement cascade, C3/5 convertase formation

Definition

C3 -- ((C3H2O+Bb),(C3b+Bb)) -> C3b -> (C3b+CFB) -- CFD -> (C3b+Bb) -> ((C3b+Bb)+CFP) -> ((C3b+Bb+C3b)+CFP)

Expanded

718 -- ((C22539+C22540),(C22533+C22540)) -> C22533 -> (C22533+629) -- 1675 -> (C22533+C22540) -> ((C22533+C22540)+5199) -> ((C22533+C22540+C22533)+5199)

Class

nt06513 Complement cascade

Type

Reference

Pathway

hsa04610

Complement and coagulation cascades

Gene

718	C3; complement C3

629	CFB; complement factor B

1675	CFD; complement factor D

5199	CFP; complement factor properdin

Metabolite

C22539

Complement C3(H2O)

C22533

Complement component 3b

C22540

Complement factor Bb

Reference

PMID:26082779

Authors

Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT

Title

Complement System Part I - Molecular Mechanisms of Activation and Regulation.

Journal

Front Immunol 6:262 (2015)
DOI:10.3389/fimmu.2015.00262

LinkDB

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