KEGG ORTHOLOGY: K18952

ORTHOLOGY: K18952

Entry

K18952                      KO

Symbol

PRKCZ

Name

atypical protein kinase C zeta type [EC:2.7.11.13]

Pathway

map04015

Rap1 signaling pathway

map04062

Chemokine signaling pathway

map04071

Sphingolipid signaling pathway

map04144

Endocytosis

map04360

Axon guidance

map04390

Hippo signaling pathway

map04530

Tight junction

map04611

Platelet activation

map04910

Insulin signaling pathway

map04926

Relaxin signaling pathway

map04930

Type II diabetes mellitus

map04931

Insulin resistance

map04933

AGE-RAGE signaling pathway in diabetic complications

map05165

Human papillomavirus infection

map05415

Diabetic cardiomyopathy

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K18952  PRKCZ; atypical protein kinase C zeta type
   04390 Hippo signaling pathway
    K18952  PRKCZ; atypical protein kinase C zeta type
   04071 Sphingolipid signaling pathway
    K18952  PRKCZ; atypical protein kinase C zeta type
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K18952  PRKCZ; atypical protein kinase C zeta type
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K18952  PRKCZ; atypical protein kinase C zeta type
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K18952  PRKCZ; atypical protein kinase C zeta type
   04062 Chemokine signaling pathway
    K18952  PRKCZ; atypical protein kinase C zeta type
  09152 Endocrine system
   04910 Insulin signaling pathway
    K18952  PRKCZ; atypical protein kinase C zeta type
   04926 Relaxin signaling pathway
    K18952  PRKCZ; atypical protein kinase C zeta type
  09158 Development and regeneration
   04360 Axon guidance
    K18952  PRKCZ; atypical protein kinase C zeta type
09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K18952  PRKCZ; atypical protein kinase C zeta type
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K18952  PRKCZ; atypical protein kinase C zeta type
   05415 Diabetic cardiomyopathy
    K18952  PRKCZ; atypical protein kinase C zeta type
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K18952  PRKCZ; atypical protein kinase C zeta type
   04931 Insulin resistance
    K18952  PRKCZ; atypical protein kinase C zeta type
   04933 AGE-RAGE signaling pathway in diabetic complications
    K18952  PRKCZ; atypical protein kinase C zeta type
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K18952  PRKCZ; atypical protein kinase C zeta type
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     K18952  PRKCZ; atypical protein kinase C zeta type
Protein kinases [BR:ko01001]
Serine/threonine kinases: AGC group
  PKC family [OT]
   K18952  PRKCZ; atypical protein kinase C zeta type

Other DBs

GO:

0004697

Genes

HSA:	5590(PRKCZ)

PTR:	743533(PRKCZ)

PPS:	100987713(PRKCZ)

GGO:	101127296(PRKCZ)

PON:	100174126(PRKCZ)

PPYG:

129010210(PRKCZ)

NLE:	100585698(PRKCZ)

HMH:	116812799(PRKCZ)

SSYN:

129471829(PRKCZ)

MCC:	710340(PRKCZ)

MCF:	101925905(PRKCZ)

MTHB:

126951757

MNI:	105496712(PRKCZ)

CSAB:

103225772(PRKCZ)

CATY:

105594441(PRKCZ)

PANU:

101020378(PRKCZ)

TGE:	112617420 112622236(PRKCZ)

MLEU:

105544659(PRKCZ)

RRO:	104653559(PRKCZ)

RBB:	108536030(PRKCZ)

TFN:	117093432(PRKCZ)

PTEH:

111544572(PRKCZ)

CANG:

105503943(PRKCZ)

CJC:	100394749(PRKCZ)

SBQ:	101039978(PRKCZ)

CIMI:

108313954(PRKCZ)

ANAN:

105727751(PRKCZ)

CSYR:

103251445(PRKCZ)

MMUR:

105877684(PRKCZ)

LCAT:

123635996(PRKCZ)

PCOQ:

105820937(PRKCZ)

OGA:	100965310(PRKCZ)

MMU:	18762(Prkcz)

MCAL:

110292460(Prkcz)

MPAH:

110322937(Prkcz)

RNO:	25522(Prkcz)

MCOC:

116095810(Prkcz)

ANU:	117708435(Prkcz)

ASYL:

127681765(Prkcz)

MUN:	110559875(Prkcz)

CGE:

100756860

MAUA:

101837450(Prkcz)

PROB:

127213543(Prkcz)

PLEU:

114708277(Prkcz)

MORG:

121443525 121448043

MFOT:

126508139

AAMP:

119816609(Prkcz)

NGI:	103749769(Prkcz)

HGL:	101699303(Prkcz)

CPOC:

100734946(Prkcz)

CCAN:

109691439(Prkcz)

DORD:

105997124(Prkcz)

DSP:	122127324(Prkcz)

PLOP:

125354478(Prkcz)

NCAR:

124983581

MMMA:

107155579(Prkcz)

OCU:	100009538(PRKCZ)

OPI:	101536130(PRKCZ)

TUP:	102503329(PRKCZ)

GVR:

103610061

CFA:	479577(PRKCZ)

CLUD:

112646980(PRKCZ)

VVP:	112926173(PRKCZ)

VLG:	121499817(PRKCZ)

NPO:	129497722(PRKCZ)

AML:	100477838(PRKCZ)

UMR:	103678447(PRKCZ)

UAH:	113270615(PRKCZ)

UAR:	123796122(PRKCZ)

ELK:

111154565

LLV:

125097025

MPUF:

101687953 106007415

MNP:	132001225(PRKCZ)

MLK:	131808860(PRKCZ)

NVS:	122899350(PRKCZ)

ORO:	101380706(PRKCZ)

EJU:	114213301(PRKCZ)

ZCA:	113924857(PRKCZ)

MLX:	118020095(PRKCZ)

NSU:	110574610(PRKCZ)

LWW:	102747056(PRKCZ)

FCA:	101087851(PRKCZ)

PYU:	121019392(PRKCZ)

PCOO:

112861986(PRKCZ)

PBG:	122479814(PRKCZ)

PVIV:

125172978(PRKCZ)

LRUF:

124516243

PTG:	102960685 102960973

PPAD:

109273956(PRKCZ)

PUC:

125913204

AJU:

106984642

HHV:	120242512(PRKCZ)

BTA:	286877(PRKCZ)

BOM:	102269695(PRKCZ)

BIU:	109570580(PRKCZ)

BBUB:

102403175(PRKCZ)

BBIS:

104995923(PRKCZ)

CHX:	102186420(PRKCZ)

OAS:	101122295(PRKCZ)

BTAX:

128061175(PRKCZ)

CSUM:

138090355(PRKCZ)

ODA:	120880614(PRKCZ)

CCAD:

122452072(PRKCZ)

MREE:

136168451(PRKCZ)

MBEZ:

129551440(PRKCZ)

SSC:	100533200(PRKCZ)

CFR:	102509870(PRKCZ)

CBAI:

105071048(PRKCZ)

CDK:	105105552(PRKCZ)

VPC:	102544003(PRKCZ)

BACU:

103004909(PRKCZ)

BMUS:

118901701(PRKCZ)

LVE:	103069979(PRKCZ)

OOR:	101283233(PRKCZ)

DLE:	111187277(PRKCZ)

PCAD:

102988631(PRKCZ)

PSIU:

116752778(PRKCZ)

NASI:

112409910(PRKCZ)

ECB:	100064240(PRKCZ)

EPZ:	103559872(PRKCZ)

EAI:	106845213(PRKCZ)

MYB:	102238785(PRKCZ) 102250265 106726938

MYD:	102773944(PRKCZ)

MMYO:

118655597(PRKCZ)

MDT:	132231774(PRKCZ)

PKL:	118732016(PRKCZ)

EFUS:

103295368(PRKCZ)

MNA:	107540144(PRKCZ)

DRO:	112299039(PRKCZ)

SHON:

118998179(PRKCZ)

AJM:	119050546(PRKCZ)

PDIC:

114496467(PRKCZ)

PHAS:

123831995(PRKCZ)

MMF:	118643394(PRKCZ)

PPAM:

129079095(PRKCZ)

HAI:	109391154(PRKCZ)

RFQ:	117026739(PRKCZ)

PALE:

102892135(PRKCZ)

PGIG:

120614115(PRKCZ)

PVP:	105303610(PRKCZ)

RAY:	107510685(PRKCZ)

MJV:	108386155(PRKCZ)

TOD:	119235999(PRKCZ)

SARA:

101557147(PRKCZ)

SFUM:

130036496

SETR:

126010949(PRKCZ)

LAV:	100673102(PRKCZ)

TMU:

101350086

ETF:	101661315(PRKCZ)

DNM:	101428270(PRKCZ)

MDO:	100020001 100020306 100030202(PRKCZ) 100617582 103103873

GAS:	123240168(PRKCZ)

SHR:	100916377(PRKCZ)

AFZ:

127555989

PCW:	110200507(PRKCZ)

TVP:	118837708(PRKCZ)

PBRV:

138154194(PRKCZ)

OAA:	100089779(PRKCZ)

GGA:	419399(PRKCZ)

PCOC:

116242568(PRKCZ)

MGP:

100538756

CJO:	107323428(PRKCZ)

TPAI:

128085020(PRKCZ)

LMUT:

125703271(PRKCZ)

NMEL:

110408649(PRKCZ)

APLA:

101801184(PRKCZ)

ACYG:

106044643(PRKCZ)

CATA:

118253440(PRKCZ)

AFUL:

116497674(PRKCZ)

TGU:	100224539(PRKCZ)

LSR:	110470326(PRKCZ)

SCAN:

103820807(PRKCZ)

PMOA:

120511046(PRKCZ)

OTC:	121344040(PRKCZ)

PRUF:

121351477(PRKCZ)

GFR:	102033231(PRKCZ)

FAB:	101816603(PRKCZ)

OMA:	130261697(PRKCZ)

PHI:	102104412(PRKCZ)

PMAJ:

107213615(PRKCZ)

CCAE:

111938628(PRKCZ)

CCW:	104693294(PRKCZ)

CBRC:

103622268(PRKCZ)

ACOE:

138121560(PRKCZ)

ETL:	114063173(PRKCZ)

ZAB:

102068830

ZLE:	135456519(PRKCZ)

ACHL:

103809176(PRKCZ)

SVG:	106857709(PRKCZ)

MMEA:

130583439(PRKCZ)

HRT:	120762219(PRKCZ)

SATI:

136370665(PRKCZ)

FPG:	101923933(PRKCZ)

FCH:	102046534(PRKCZ)

CCRI:

104168954(PRKCZ)

NNT:	104410221(PRKCZ)

SHAB:

115617548(PRKCZ)

ACUN:

113487762(PRKCZ)

TALA:

104358148(PRKCZ)

ACHC:

115342746(PRKCZ)

HALD:

104324057(PRKCZ)

HLE:	104837967(PRKCZ)

AGEN:

126043377

HHAR:

128143719(PRKCZ)

GCL:

127024705

CSTI:

104560464(PRKCZ)

LDI:

104341337

MNB:	103776392(PRKCZ)

DPUB:

104305894(PRKCZ)

PPUS:

135190501(PRKCZ)

AVIT:

104268374(PRKCZ)

BRHI:

104492421(PRKCZ)

EGZ:	104134560(PRKCZ)

NNI:	104008940(PRKCZ)

PCRI:

104034721(PRKCZ)

PADL:

103917923(PRKCZ)

AFOR:

103894709(PRKCZ)

FGA:	104069836(PRKCZ)

GSTE:

104257741(PRKCZ)

CLV:	102088471(PRKCZ)

MUI:	104543177(PRKCZ)

PGUU:

104468000(PRKCZ)

PLET:

104627615(PRKCZ)

EHS:	104512343(PRKCZ)

CMAC:

104473741(PRKCZ)

CUCA:

104059830(PRKCZ)

TEO:	104378771(PRKCZ)

BREG:

104629858(PRKCZ)

OHA:	104329331(PRKCZ)

ACAR:

104524406

CPEA:

104395491(PRKCZ)

CVF:	104290507(PRKCZ)

RTD:	128918233(PRKCZ)

AAM:	106485752(PRKCZ)

AROW:

112975490(PRKCZ)

NPD:	112957501(PRKCZ)

TGT:	104577942(PRKCZ)

DNE:	112981121(PRKCZ)

SCAM:

104141940(PRKCZ)

ASN:	102378910(PRKCZ)

AMJ:	102560314(PRKCZ)

CPOO:

109314248(PRKCZ)

GGN:	109293644(PRKCZ)

PSS:	102463465(PRKCZ)

CMY:	102936764(PRKCZ)

CCAY:

125624232(PRKCZ)

DCC:	119844928(PRKCZ)

CPIC:

101932516(PRKCZ)

TST:	117867990(PRKCZ)

CABI:

116826670

MRV:	120387858(PRKCZ)

ASAO:

132764871(PRKCZ)

PVT:	110091005(PRKCZ)

SUND:

121936709(PRKCZ)

PBI:	103058747(PRKCZ)

PMUR:

107290687(PRKCZ)

CTIG:

120318944(PRKCZ)

TSR:	106547252 106550150

PGUT:

117675831(PRKCZ)

APRI:

131187079(PRKCZ)

PTEX:

113446163(PRKCZ)

NSS:	113421297(PRKCZ)

VKO:	123031008(PRKCZ)

PMUA:

114602552(PRKCZ)

PRAF:

128419685(PRKCZ)

ZVI:	118085893(PRKCZ)

HCG:	128338721(PRKCZ)

GJA:	107110190(PRKCZ)

STOW:

125445667(PRKCZ)

EMC:	129344516(PRKCZ)

XLA:	108697633(prkcz.S) 373768(prkcz.L)

XTR:	100101769(prkcz)

NPR:	108784335(PRKCZ)

RTEM:

120915416(PRKCZ)

BBUF:

120997434(PRKCZ)

BGAR:

122928724(PRKCZ)

MUO:	115456502(PRKCZ)

GSH:	117349075(PRKCZ)

DRE:	555737(prkcz)

SRX:	107710919 107743854

SANH:

107657904(prkcz) 107700421

SGH:	107548418 107599823

CCAR:

109089670 109095435 109095450

CAUA:

113069862 113107093

CGIB:

127963979 128018815

PTET:

122350343(prkcz)

LROH:

127170059(prkcz)

OMC:	131545615(prkcz)

PPRM:

120482077(prkcz)

RKG:	130073367(prkcz)

MAMB:

125279269(prkcz)

CIDE:

127517663

CERY:

137026953(prkcz)

MASI:

127414530 127424282

TROS:

130568638(prkcz)

TDW:	130439805(prkcz)

MANU:

129413470(prkcz)

IPU:	108265357(prkcz)

PHYP:

113525518

SMEO:

124399710(prkcz)

TFD:	113658737(prkcz)

TVC:	132854218(prkcz)

TRN:	134318609(prkcz)

AMEX:

103044996(prkcz)

CMAO:

118813994(prkcz)

EEE:

113586870

CHAR:

105912330

TRU:	105419958(prkcz)

TFS:	130529864(prkcz)

TNG:	GSTEN00008686G001

LCO:	104934251(prkcz)

TBEN:

117494715(prkcz)

CGOB:

115010493(prkcz)

PGEO:

117449019(prkcz)

GACU:

117541505(prkcz)

EMAC:

134870463(prkcz)

ELY:	117258945(prkcz)

EFO:	125891995(prkcz)

PLEP:

121947050(prkcz)

SLUC:

116058169(prkcz)

ECRA:

117947180(prkcz)

ESP:	116693186(prkcz)

PFLV:

114558201(prkcz)

GAT:	120829382(prkcz)

PPUG:

119202427(prkcz) 119222620

AFB:	129100061(prkcz)

CLUM:

117733748(prkcz)

PSWI:

130199768(prkcz)

CANA:

137799965(prkcz)

CVE:	137889212(prkcz)

MSAM:

119905992(prkcz)

SCHU:

122882939(prkcz)

CUD:	121517645(prkcz)

SPUL:

138589973(prkcz)

ALAT:

119022864(prkcz)

ASTR:

137603012(prkcz)

MZE:

101487335

ONL:

100703104

OAU:	116326586(prkcz)

OLA:	101164401(prkcz)

OML:	112141323(prkcz)

CSAI:

133456894(prkcz)

XMA:	102219936(prkcz)

XCO:	114141996(prkcz)

XHE:	116721085(prkcz)

PRET:

103466966(prkcz)

PFOR:

103150454(prkcz)

PLAI:

106961545(prkcz)

PMEI:

106932765(prkcz)

GAF:	122820095(prkcz)

PPRL:

129371714(prkcz)

CVG:	107094452(prkcz)

CTUL:

119772566(prkcz)

GMU:	124868029(prkcz)

NFU:	107391401(prkcz)

KMR:	108250564(prkcz)

ALIM:

106525923

NWH:	119417777(prkcz)

AOCE:

111572559

EJA:	138210150(prkcz)

BFRE:

138633732(prkcz)

MCEP:

125019254(prkcz)

CSEM:

103384734(prkcz)

POV:	109639649(prkcz)

SSEN:

122777364

HHIP:

117765132(prkcz)

HSP:	118111455(prkcz)

PPLT:

128442059(prkcz)

SMAU:

118316305(prkcz)

LCF:

108900525

SDU:	111233799(prkcz)

SLAL:

111658840(prkcz)

XGL:	120803702(prkcz)

HCQ:	109528596(prkcz)

SSCV:

125987861(prkcz)

SBIA:

133512142(prkcz)

PEE:	133408500(prkcz)

PTAO:

133486900(prkcz)

BPEC:

110175813

MALB:

109972134(prkcz)

BSPL:

114858626(prkcz)

SJO:	128357177(prkcz)

SASA:

106567356(prkcz) 106572815

STRU:

115165374 115168951(prkcz)

OTW:	112233897 112235201

OMY:	110491852 110531259

OGO:	124032350 124046183

ONE:	115102597(prkcz) 115123275

OKI:	109869631 109878875

OKE:	118360221 127913179

SALP:

111966155 111977153(prkcz)

SNH:	120058789 120060873

CCLU:

121537681 121545929(prkcz)

ELS:	105023788(prkcz)

SFM:	108924928(prkcz)

PKI:

111859097

AANG:

118207554(prkcz)

CCOG:

133139180(prkcz)

LOC:	102689231(prkcz)

PSPA:

121328449 121328637(prkcz)

ARUT:

117425545 117962360

PSEX:

120531052

LCM:	102364882(PRKCZ)

CMK:	103184213(prkcz)

RTP:	109913955(prkcz)

CPLA:

122540381(prkcz)

HOC:	132833827(prkcz)

LERI:

AEC:

RSAN:

RMP:

VDE:

VJA:

OSN:

MLR:	MELLADRAFT_94327

» show all

Reference

PMID:2470089

Authors

Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K, Nishizuka Y

Title

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

Journal

Proc Natl Acad Sci U S A 86:3099-103 (1989)
DOI:10.1073/pnas.86.9.3099

Sequence

[rno:25522]

LinkDB

DBGET integrated database retrieval system