Entry
Name
Leuprolide mesylate; Leuprorelin mesylate; Leuprorelin mesilate; Camcevi (TN)
Product
Formula
C59H84N16O12. CH4SO3
Exact mass
1304.6336
Mol weight
1305.51
Structure
Mol file KCF file DB search
Class
Hormonal agent
DG01494 Gonadotropin-releasing hormone receptor agonist
Remark
Product (DG00730): D00989<JP /US > D12337<US>
Efficacy
Antineoplastic, Gonadotropin-releasing hormone receptor agonist
Disease
Target
Pathway
hsa04080 Neuroactive ligand-receptor interaction
Interaction
DDI search
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02A HORMONES AND RELATED AGENTS
L02AE Gonadotropin releasing hormone analogues
L02AE02 Leuprorelin
D12337 Leuprolide mesylate <US>
Drug groups [BR:br08330 ]
Hormonal agent
DG01494 Gonadotropin-releasing hormone receptor agonist
DG00730 Leuprorelin
D12337 Leuprolide mesylate
Target-based classification of drugs [BR:br08310 ]
G Protein-coupled receptors
Rhodopsin family
Gonadotropin-releasing hormone
GNRHR
D12337 Leuprolide mesylate <US>
New drug approvals in Europe [br08329.html ]
European public assessment reports (EPAR) authorised medicine
D12337
Drug groups [BR:br08330 ]
Hormonal agent
DG01494 Gonadotropin-releasing hormone receptor agonist
DG00730 Leuprorelin
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 92
1 C1c C 11.0540 -15.7415
2 N1b N 9.8647 -16.3712
3 C5a C 12.3134 -16.3712
4 C5a C 8.6753 -15.7415
5 N1b N 13.4328 -15.6716
6 O5a O 12.3134 -17.7005
7 C1c C 7.4860 -16.4411
8 O5a O 8.6753 -14.2723
9 C1c C 14.6221 -16.3012
10 N1b N 6.2266 -15.7415
11 C5a C 15.8814 -15.6716
12 C5a C 5.0373 -16.4411
13 N1b N 17.0708 -16.3012
14 O5a O 15.8814 -14.2023
15 C1y C 3.8479 -15.8115
16 O5a O 5.0373 -17.8404
17 C1c C 18.2602 -15.6016
18 C1x C 2.5886 -16.2313
19 N1x N 3.8479 -14.3423
20 C1b C 18.2602 -14.2023
21 C5a C 19.4495 -16.3012
22 C1x C 1.7491 -15.0419
23 C5x C 2.5886 -13.9925
24 C8y C 19.3796 -13.5027
25 N1b N 20.7088 -15.6016
26 O5a O 19.4495 -17.7005
27 O5x O 2.0989 -12.6632
28 C8x C 20.7088 -14.1324
29 C8x C 19.3796 -12.1035
30 C1c C 21.9682 -16.3012
31 C8x C 21.8982 -13.4328
32 C8x C 20.6389 -11.4039
33 C5a C 23.1575 -15.6016
34 C8y C 21.8982 -12.1035
35 N1b N 24.3469 -16.3012
36 O5a O 23.1575 -14.1324
37 O1a O 23.0176 -11.4039
38 C1c C 25.5362 -15.6016
39 C5a C 26.7256 -16.2313
40 N1b N 27.9150 -15.5316
41 O5a O 26.7256 -17.6305
42 C1c C 29.1043 -16.2313
43 C5a C 30.3636 -15.5316
44 C1b C 29.1043 -17.6305
45 N1y N 31.6230 -16.1613
46 O5a O 30.3636 -14.0624
47 C1y C 32.9522 -16.1613
48 C1x C 31.2032 -17.4906
49 C1x C 33.3720 -17.4906
50 C5a C 34.2815 -15.4617
51 C1x C 32.2526 -18.2602
52 N1b N 35.5408 -16.2313
53 O5a O 34.2815 -13.9225
54 C1b C 11.0540 -14.2723
55 C8y C 12.3833 -13.6426
56 C8y C 12.8031 -12.3833
57 C8x C 13.5027 -14.4122
58 C8y C 14.1324 -12.3833
59 C8x C 12.1035 -11.1940
60 N4x N 14.6221 -13.6426
61 C8x C 14.8320 -11.1240
62 C8x C 12.8031 -9.9346
63 C8x C 14.1324 -9.9346
64 C1b C 7.4860 -17.8404
65 C8y C 8.6753 -18.5400
66 C8x C 8.6753 -19.9393
67 N5x N 9.9346 -20.4290
68 C8x C 10.7742 -19.3096
69 N4x N 10.0746 -18.1202
70 C1b C 14.6221 -17.7005
71 O1a O 15.8814 -18.4001
72 C1b C 21.9682 -17.7005
73 C1c C 23.2275 -18.4001
74 C1a C 24.4168 -17.6305
75 C1a C 23.2275 -19.7993
76 C1b C 25.5362 -14.1324
77 C1c C 26.7256 -13.4328
78 C1a C 27.9849 -14.2023
79 C1a C 26.7256 -12.0335
80 C1b C 36.8002 -15.5316
81 C1a C 37.9895 -16.2313
82 C1b C 30.3636 -18.3301
83 C1b C 30.3636 -19.7993
84 N1b N 29.1043 -20.4989
85 C2c C 27.9150 -19.7993
86 N1a N 26.7256 -20.4989
87 N2a N 27.9150 -18.3301
88 S4a S 36.9600 -20.5800
89 C1a C 35.5600 -20.5800
90 O1d O 38.3600 -20.5800
91 O1d O 36.9600 -19.1800
92 O1d O 36.9600 -21.9800
BOND 96
1 1 2 1
2 1 3 1
3 2 4 1
4 3 5 1
5 3 6 2
6 4 7 1
7 4 8 2
8 5 9 1
9 7 10 1
10 9 11 1
11 10 12 1
12 11 13 1
13 11 14 2
14 15 12 1 #Down
15 12 16 2
16 13 17 1
17 15 18 1
18 15 19 1
19 17 20 1 #Up
20 17 21 1
21 18 22 1
22 19 23 1
23 20 24 1
24 21 25 1
25 21 26 2
26 23 27 2
27 24 28 2
28 24 29 1
29 25 30 1
30 28 31 1
31 29 32 2
32 30 33 1
33 31 34 2
34 33 35 1
35 33 36 2
36 34 37 1
37 35 38 1
38 38 39 1
39 39 40 1
40 39 41 2
41 40 42 1
42 42 43 1
43 42 44 1 #Down
44 43 45 1
45 43 46 2
46 45 47 1
47 45 48 1
48 47 49 1
49 47 50 1 #Down
50 48 51 1
51 50 52 1
52 50 53 2
53 22 23 1
54 32 34 1
55 49 51 1
56 1 54 1 #Up
57 54 55 1
58 55 56 1
59 56 58 2
60 56 59 1
61 57 60 1
62 58 61 1
63 59 62 2
64 61 63 2
65 58 60 1
66 62 63 1
67 57 55 2
68 7 64 1 #Down
69 64 65 1
70 65 66 2
71 66 67 1
72 67 68 2
73 68 69 1
74 69 65 1
75 9 70 1 #Down
76 70 71 1
77 30 72 1 #Down
78 72 73 1
79 73 74 1
80 73 75 1
81 38 76 1 #Up
82 76 77 1
83 77 78 1
84 77 79 1
85 52 80 1
86 80 81 1
87 44 82 1
88 82 83 1
89 83 84 1
90 84 85 1
91 85 86 1
92 85 87 2
93 88 89 1
94 88 90 1
95 88 91 2
96 88 92 2