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KEGG   DRUG: Elafibranor
Entry
D11208                      Drug                                   
Name
Elafibranor (USAN);
Iqirvo (TN)
Product
IQIRVO (Ipsen Biopharmaceuticals)
Formula
C22H24O4S
Exact mass
384.1395
Mol weight
384.49
Structure
Class
Metabolizing enzyme inducer
 DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer
Remark
ATC code: A05AX06
Product: D11208<US>
Efficacy
Antihyperlipidemic, Peroxisome proliferator-activated receptor (PPAR) alpha agonist
  Disease
Primary biliary cholangitis [DS:H01467]
Comment
Treatment of non-alcoholic steato-hepatitis, reducing cardiometabolic risk factors in patients with diabetes and pre-diabetes
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294]
  Pathway
hsa03320  PPAR signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04932  Non-alcoholic fatty liver disease
Interaction
CYP induction: CYP3A4 [HSA:1576]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A05 BILE AND LIVER THERAPY
   A05A BILE THERAPY
    A05AX Other drugs for bile therapy
     A05AX06 Elafibranor
      D11208  Elafibranor (USAN) <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Elafibranor
    D11208  Elafibranor (USAN)
Drug groups [BR:br08330]
 Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    D11208  Elafibranor
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C1 (PPARA)
     D11208  Elafibranor (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11208
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11208
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11208
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11208
Other DBs
CAS: 824932-88-9
PubChem: 384585186
PDB-CCD: MUO[PDBj]
LinkDB
KCF data

ATOM        27
            1   C8x C     9.3800  -17.7100
            2   C8y C     9.3800  -16.3100
            3   C8x C    10.5700  -15.6100
            4   C8x C    11.8300  -16.3100
            5   C8y C    11.8300  -17.7100
            6   C8x C    10.5700  -18.4100
            7   C5a C    13.0200  -18.4100
            8   C2b C    14.2100  -17.7100
            9   O5a O    13.0200  -19.8100
            10  C2b C    15.4000  -18.4100
            11  C8y C    16.5900  -17.7100
            12  C8x C    16.5900  -16.3100
            13  C8y C    17.8500  -15.6100
            14  C8y C    19.0400  -16.3100
            15  C8y C    19.0400  -17.7100
            16  C8x C    17.8500  -18.4100
            17  C1a C    17.8500  -14.2100
            18  O2a O    20.2300  -15.6100
            19  C1d C    21.4200  -16.3100
            20  C6a C    22.6100  -15.6100
            21  O6a O    23.8000  -16.3100
            22  O6a O    22.6100  -14.2100
            23  C1a C    20.0200  -19.1100
            24  C1a C    20.7200  -17.5000
            25  C1a C    22.1200  -17.5000
            26  S2a S     8.1900  -15.6100
            27  C1a C     7.0000  -16.3100
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 2
            10    8  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18   13  17 1
            19   14  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   20  22 2
            24   15  23 1
            25   19  24 1
            26   19  25 1
            27    2  26 1
            28   26  27 1

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