KEGG DRUG: Andexanet alfa

DRUG: Andexanet alfa

Entry

D11029                      Drug

Name

Andexanet alfa (USAN/INN);
Andexanet alfa (genetical recombination) (JAN);
Andexxa (TN);
Ondexxya (TN)

Product

ANDEXXA (AstraZeneca Pharmaceuticals LP)

Sequence

(heavy chain)
IVGGQECKDG ECPWQALLIN EENEGFCGGT ILSEFYILTA AHCLYQAKRF KVRVGDRNTE
QEEGGEAVHE VEVVIKHNRF TKETYDFDIA VLRLKTPITF RMNVAPACLP ERDWAESTLM
TQKTGIVSGF GRTHEKGRQS TRLKMLEVPY VDRNSCKLSS SFIITQNMFC AGYDTKQEDA
CQGDAGGPHV TRFKDTYFVT GIVSWGEGCA RKGKYGIYTK VTAFLKWIDR SMKTRGLPKA
KSHAPEVITS SPLK
(light chan)
ANSFLFWNKY KDGDQCETSP CQNQGKCKDG LGEYTCTCLE GFEGKNCELF TRKLCSLDNG
DCDQFCHEEQ NSVVCSCARG YTLADNGKAC IPTGPYPCGK QTLER
(Disulfide bridge: H7-H12, H27-H43, H108-L98, H156-H170, H181-H209, L16-L27, L21-L36, L38-L47, L55-L66, L62-L75, L77-L90)

Type

Peptide

Class

Blood modifier agent
DG01950 Antithrombotic agent
DG01662 Factor Xa inhibitor

Remark

Therapeutic category:

3399

ATC code:

V03AB38

Product:

D11029<JP/US>

Efficacy

Anticoagulant reversal (factor Xa inhibitors)

Comment

Ligand decoy
Reversal of anticoagulation caused by factor Xa inhibitors

Target

F10 [HSA:2159] [KO:K01314]

Pathway

hsa04610

Complement and coagulation cascades

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB38 Andexanet alfa
      D11029  Andexanet alfa (USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D11029  Andexanet alfa (USAN/INN); Andexanet alfa (genetical recombination) (JAN)
Drug groups [BR:br08330]
Blood modifier agent
  DG01950  Antithrombotic agent
   DG01662  Factor Xa inhibitor
    D11029  Andexanet alfa
Target-based classification of drugs [BR:br08310]
Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F10
     D11029  Andexanet alfa (USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D11029
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D11029
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D11029

Other DBs

CAS:	1262449-58-0

PubChem:

350078348

LinkDB

» Japanese version » Back

DBGET integrated database retrieval system