Entry
Name
Valemetostat tosilate (JAN); Valemetostat tosylate; Ezharmia (TN)
Formula
C26H34ClN3O4. C7H8O3S
Exact mass
659.2432
Mol weight
660.22
Structure
Mol file KCF file DB search
Remark
Therapeutic category: 4291
Product (DG03075): D11662<JP >
Efficacy
Antineoplastic, histone methyltransferase inhibitor
Target
Pathway
Interaction
DDI search
Brite
Therapeutic category of drugs in Japan [BR:br08301 ]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D11662 Valemetostat tosilate (JAN)
Target-based classification of drugs [BR:br08310 ]
Enzymes
Transferases (EC2)
Methyltransferases
EZH
D11662 Valemetostat tosilate (JAN) <JP>
New drug approvals in Japan [br08318.html ]
Drugs with new active ingredients
D11662
New drug approvals in the USA, Europe and Japan [br08328.html ]
Approval dates by FDA, EMA and PMDA
D11662
BRITE hierarchy
Other DBs
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KCF data
Show ATOM 45
1 C8x C 27.1031 -15.4775
2 C8y C 27.1031 -16.8782
3 N4x N 25.9125 -17.5785
4 C8y C 24.6519 -16.8782
5 C8y C 24.6519 -15.4775
6 C8y C 25.9125 -14.7772
7 C1b C 23.4614 -14.7772
8 N1b N 22.2708 -15.4775
9 C5a C 21.0802 -14.7772
10 C8y C 19.8896 -15.4775
11 O5a O 21.0802 -13.3765
12 C8x C 19.8896 -16.8782
13 C8y C 18.6990 -17.5785
14 C8y C 17.5085 -16.8782
15 C8y C 17.5085 -15.4775
16 C8y C 18.6990 -14.7772
17 C1a C 18.6990 -13.3765
18 X Cl 18.6990 -18.9792
19 O2x O 16.1778 -17.2984
20 C1z C 15.3374 -16.1778
21 O2x O 16.1778 -14.9873
22 C1y C 13.9367 -16.1778
23 C1a C 14.7071 -17.4384
24 C1x C 13.2364 -17.3684
25 C1x C 11.8357 -17.3684
26 C1y C 11.1354 -16.1778
27 C1x C 11.8357 -14.9172
28 C1x C 13.2364 -14.9172
29 N1c N 9.7347 -16.1778
30 C1a C 9.0344 -17.3684
31 C1a C 9.0344 -14.9873
32 C1a C 25.9125 -13.3765
33 O5x O 23.4614 -17.5785
34 C1a C 28.2937 -17.5785
35 C8x C 31.2200 -16.3100
36 C8x C 31.2200 -17.7100
37 C8y C 32.4324 -18.4100
38 C8x C 33.6449 -17.7100
39 C8x C 33.6449 -16.3100
40 C8y C 32.4324 -15.6100
41 C1a C 32.4324 -19.8098
42 S4a S 32.4324 -14.2102
43 O1d O 31.0324 -14.2102
44 O1d O 33.8324 -14.2102
45 O1d O 32.4324 -12.8102
BOND 48
1 1 2 2
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 9 11 2
12 10 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 15 16 2
17 10 16 1
18 16 17 1
19 13 18 1
20 14 19 1
21 19 20 1
22 20 21 1
23 15 21 1
24 20 22 1
25 20 23 1 #Up
26 22 24 1
27 24 25 1
28 25 26 1
29 26 27 1
30 27 28 1
31 22 28 1
32 26 29 1 #Down
33 29 30 1
34 29 31 1
35 6 32 1
36 4 33 2
37 2 34 1
38 35 36 2
39 36 37 1
40 37 38 2
41 38 39 1
42 39 40 2
43 35 40 1
44 37 41 1
45 40 42 1
46 42 43 2
47 42 44 2
48 42 45 1