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KEGG   DRUG: Galcanezumab
Entry
D10936                      Drug                                   
Name
Galcanezumab (USAN/INN);
Galcanezumab (genetical recombination) (JAN);
Galcanezumab-gnlm;
Emgality (TN)
Product
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYTFG NYWMQWVRQA PGQGLEWMGA IYEGTGKTVY
IQKFADRVTI TADKSTSTAY MELSSLRSED TAVYYCARLS DYVSGFGYWG QGTTVTVSSA
STKGPSVFPL APCSRSTSES TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTKTY TCNVDHKPSN TKVDKRVESK YGPPCPPCPA PEAAGGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSQEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTYR
VVSVLTVLHQ DWLNGKEYKC KVSNKGLPSS IEKTISKAKG QPREPQVYTL PPSQEEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSRLT VDKSRWQEGN
VFSCSVMHEA LHNHYTQKSL SLSLG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASKDIS KYLNWYQQKP GKAPKLLIYY TSGYHSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ GDALPPTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H133-L214, H146-H202, H225-H'225, H228-H'228, H260-H320, H366-H424, H'22-H'96, H'133-L'214, H'146-H'202, H'260-H'320, H'366-H'424, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Remark
Therapeutic category: 1190
ATC code: N02CD02
Product: D10936<JP/US>
Efficacy
Analgesic, Antimigraine, Anti-calcitonin gene related peptide (GCRP) antibody
  Type
Monoclonal antibody
Comment
Preventive treatment of migraine
Target
CALCA (CGRP) [HSA:796] [KO:K12332]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CD Calcitonin gene-related peptide (CGRP) antagonists
     N02CD02 Galcanezumab
      D10936  Galcanezumab (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antimigraine Agents
  Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist
   Galcanezumab
    D10936  Galcanezumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D10936  Galcanezumab (USAN/INN); Galcanezumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Neuropeptides
   Neuropeptides (GPCR-binding)
    CALCA (CGRP)
     D10936  Galcanezumab (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10936
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10936
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10936
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10936
Other DBs
CAS: 1578199-75-3
PubChem: 346930785
LinkDB

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