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KEGG   DRUG: Umeclidinium bromide and vilanterol
Entry
D10533            Mixture   Drug                                   
Name
Umeclidinium bromide and vilanterol;
Anoro (TN)
Product
Component
Umeclidinium bromide [DR:D10181], (Vilanterol trifenatate [DR:D09697] | Vilanterol [DR:D09696])
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2259
ATC code: R03AL03
Product: D10533<JP/US>
Efficacy
Bronchodilator
  Disease
Chronic obstructive pulmonary disease [DS:H01714]
Comment
Umeclidinium bromide is primarily metabolized by CYP2D6.
Vilanterol trifenatate is primarily metabolized by CYP3A4.
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AL Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
     R03AL03 Vilanterol and umeclidinium bromide
      D10533  Umeclidinium bromide and vilanterol <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilator Combinations
   Umeclidinium/ Vilanterol
    D10533  Umeclidinium bromide and vilanterol
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2259  Others
     D10533  Umeclidinium bromide and vilanterol
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01455  beta-Adrenergic receptor agonist
    DG01453  beta3-Adrenergic receptor agonist
     D10533  Umeclidinium bromide and vilanterol
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D10533  Umeclidinium bromide and vilanterol
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D10533  Umeclidinium bromide and vilanterol
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10533
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10533
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10533
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10533
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10533
Other DBs
PubChem: 254741495
LinkDB

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