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KEGG   DRUG: Plecanatide
Entry
D09948                      Drug                                   
Name
Plecanatide (USAN/INN);
Trulance (TN)
Product
Formula
C65H104N18O26S4
Exact mass
1680.6252
Mol weight
1681.90
Sequence
Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu
(Disulfide bridge: 4-12, 7-15)
  Type
Peptide
Remark
ATC code: A06AX07
Product: D09948<US>
Efficacy
Peristaltic accelerator, Enterotoxin receptor agonist
  Disease
Irritable bowel syndrome [DS:H01615]
Comment
synthetic analog of Uroguanylin [CPD:C16006]
Chronic constipation, irritable bowel syndrome with constipation
Target
GUCY2C [HSA:2984] [KO:K12320]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AX Other drugs for constipation
     A06AX07 Plecanatide
      D09948  Plecanatide (USAN/INN) <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Anti-constipation Agents
   Plecanatide
    D09948  Plecanatide (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Phosphorus-oxygen lyases
    GUCY2C
     D09948  Plecanatide (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09948
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09948
Other DBs
CAS: 467426-54-6
PubChem: 124490630
LinkDB

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