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KEGG   DRUG: Phenytoin and phenobarbital
Entry
D07583            Mixture   Drug                                   
Name
Phenytoin and phenobarbital;
Aleviatin with phenobarbital (TN)
Component
Phenytoin [DR:D00512], Phenobarbital [DR:D00506]
Class
Neuropsychiatric agent
 DG03199  Antiepileptic agent
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
Metabolizing enzyme inducer
 DG02891  CYP2B6 inducer
 DG02853  CYP3A/CYP3A4 inducer
Transporter inducer
 DG01893  ABCB1 inducer
Remark
Therapeutic category: 1139
ATC code: N03AB52
Product: D07583<JP>
Efficacy
Antiepileptic
Comment
Phenytoin is metabolized by CYP2C9 with some contribution from CYP2C19, and it is an inducer of CYP3A, CYP2B6 and P-gp.
Phenobarbital is an inducer of CYP3A.
Metabolism
Enzyme: CYP2C9 [HSA:1559]; CYP2C19 [HSA:1557]
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555]
Transporter induction: ABCB1 [HSA:5243]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AB Hydantoin derivatives
     N03AB52 Phenytoin, combinations
      D07583  Phenytoin and phenobarbital <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D07583  Phenytoin and phenobarbital
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D07583  Phenytoin and phenobarbital
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D07583  Phenytoin and phenobarbital
  DG01639  CYP2C19 substrate
   D07583  Phenytoin and phenobarbital
 Metabolizing enzyme inducer
  DG02891  CYP2B6 inducer
   D07583  Phenytoin and phenobarbital
  DG02853  CYP3A/CYP3A4 inducer
   D07583  Phenytoin and phenobarbital
 Transporter inducer
  DG01893  ABCB1 inducer
   D07583  Phenytoin and phenobarbital
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D07583  Phenytoin and phenobarbital
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07583
 Drug transporters
  D07583
Other DBs
PubChem: 96024446
LinkDB

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