| Entry |
|
|---|
| Name |
Indoramin (USAN/INN) |
|---|
| Formula |
C22H25N3O
|
|---|
| Exact mass |
347.1998
|
|---|
| Mol weight |
347.45
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG01739 Peripherally-acting antiadrenergic
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, alpha1-Adrenergic receptor antagonist |
|---|
| Comment |
Indole derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
C02CA Alpha-adrenoreceptor antagonists
C02CA02 Indoramin
D04531 Indoramin (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00254 Indoramin
D04531 Indoramin
DG01739 Peripherally-acting antiadrenergic
DG00254 Indoramin
D04531 Indoramin
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D04531 Indoramin (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00254 Indoramin
DG01739 Peripherally-acting antiadrenergic
DG00254 Indoramin
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 26
1 C8x C 5.8100 -17.2900
2 C8x C 5.8100 -18.6900
3 C8x C 7.0224 -19.3900
4 C8y C 8.2349 -18.6900
5 C8y C 8.2349 -17.2900
6 C8x C 7.0224 -16.5900
7 N4x N 9.5664 -19.1226
8 C8x C 10.3893 -17.9900
9 C8y C 9.5664 -16.8574
10 C1b C 9.5664 -15.4574
11 C1b C 10.7908 -14.7502
12 N1y N 12.0037 -15.4502
13 C1x C 12.0044 -16.8696
14 C1x C 13.2172 -17.5690
15 C1y C 14.4292 -16.8684
16 C1x C 14.4285 -15.4490
17 C1x C 13.2157 -14.7496
18 N1b N 15.6358 -17.5642
19 C5a C 16.8259 -16.8761
20 C8y C 18.0166 -17.5628
21 O5a O 16.8253 -15.4702
22 C8x C 18.0174 -18.9697
23 C8x C 19.2302 -19.6690
24 C8x C 20.4423 -18.9683
25 C8x C 20.4415 -17.5614
26 C8x C 19.2286 -16.8621
BOND 29
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 2
10 5 9 1
11 9 10 1
12 10 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 12 17 1
20 15 18 1
21 18 19 1
22 19 20 1
23 19 21 2
24 20 22 2
25 22 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 20 26 1
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