| Entry |
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| Name |
Mometasone furoate hydrate (JAN);
Mometasone furoate monohydrate;
Nasonex (TN) |
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| Product |
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| Generic |
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| Formula |
C27H30Cl2O6. H2O
|
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| Exact mass |
538.1525
|
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| Mol weight |
539.44
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 1329 |
| Product (DG00419): | D00690<JP/US> D03325<JP/US> |
| Product (mixture): | D10295<US> D12501<US> |
|
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| Efficacy |
Antiallergic, Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AC Corticosteroids, potent (group III)
D07AC13 Mometasone
D03325 Mometasone furoate hydrate (JAN) <JP/US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XC Corticosteroids, potent, other combinations
D07XC03 Mometasone
D03325 Mometasone furoate hydrate (JAN) <JP/US>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD09 Mometasone
D03325 Mometasone furoate hydrate (JAN) <JP/US>
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
R03BA Glucocorticoids
R03BA07 Mometasone
D03325 Mometasone furoate hydrate (JAN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, Medium Potency
Mometasone
D03325 Mometasone furoate hydrate (JAN)
Respiratory Tract/Pulmonary Agents
Anti-inflammatories, Inhaled Corticosteroids
Mometasone
D03325 Mometasone furoate hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
132 Otic and nasal agents
1329 Others
D03325 Mometasone furoate hydrate (JAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00419 Mometasone
D03325 Mometasone furoate hydrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00419 Mometasone
D03325 Mometasone furoate hydrate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D03325 Mometasone furoate hydrate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D03325 Mometasone furoate hydrate (JAN) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D03325
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03325
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00419 Mometasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00419 Mometasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 36
1 O0 O 40.5985 -18.7593
2 C1z C 32.6900 -17.8500
3 C1z C 31.5700 -18.5500
4 C1y C 33.8800 -18.5500
5 O7a O 34.5800 -16.7300
6 C5a C 32.6900 -16.5200
7 C1y C 31.5700 -19.8800
8 C1x C 30.3800 -17.8500
9 C1a C 31.5700 -17.1500
10 C1x C 33.8800 -19.8800
11 C1a C 35.2100 -18.9000
12 C7a C 35.9800 -16.7300
13 C1b C 33.8800 -15.8200
14 O5a O 31.5000 -15.8200
15 C1y C 30.3800 -20.5800
16 C1y C 29.1900 -18.5500
17 C8y C 36.6100 -15.6100
18 O6a O 36.6100 -17.9200
19 X Cl 33.8800 -14.4200
20 C1z C 29.1900 -19.8800
21 C1x C 30.3800 -21.9100
22 O1a O 28.0700 -17.8500
23 C8x C 38.0100 -15.6100
24 O2x O 36.1900 -14.2800
25 C1z C 28.0700 -20.5800
26 X Cl 29.1900 -21.2100
27 C1x C 29.1900 -22.6100
28 C8x C 38.4300 -14.2800
29 C8x C 37.3100 -13.4400
30 C2y C 28.0700 -21.9100
31 C2x C 26.8800 -19.8800
32 C1a C 28.0000 -19.1800
33 C2x C 26.8800 -22.6100
34 C2x C 25.6900 -20.5800
35 C5x C 25.6900 -21.9100
36 O5x O 24.5000 -22.5400
BOND 39
1 2 3 1
2 2 4 1
3 2 5 1 #Down
4 2 6 1 #Up
5 3 7 1
6 3 8 1
7 3 9 1 #Up
8 4 10 1
9 4 11 1 #Down
10 5 12 1
11 6 13 1
12 6 14 2
13 7 15 1
14 8 16 1
15 12 17 1
16 12 18 2
17 13 19 1
18 15 20 1
19 15 21 1
20 16 22 1 #Up
21 17 23 2
22 17 24 1
23 20 25 1
24 20 26 1 #Down
25 21 27 1
26 23 28 1
27 24 29 1
28 25 30 1
29 25 31 1
30 25 32 1 #Up
31 30 33 2
32 31 34 2
33 33 35 1
34 35 36 2
35 7 10 1
36 16 20 1
37 27 30 1
38 28 29 2
39 34 35 1
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