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KEGG   DRUG: Eculizumab
Entry
D03940                      Drug                                   
Name
Eculizumab (USAN/INN);
Eculizumab (genetical recombination) (JAN);
Soliris (TN)
Product
Remark
Therapeutic category: 6399
ATC code: L04AJ01
Product: D03940<JP/US>
Efficacy
Immunosuppressant, Anti-complement C5 antibody
  Disease
Paroxysmal nocturnal hemoglobinuria [DS:H01053]
Atypical hemolytic uremic syndrome [DS:H01434]
Generalized myasthenia gravis (AChR antibody positive) [DS:H01594]
Neuromyelitis optica spectrum disorder (anti-AQP4 antibody positive) [DS:H01491]
  Type
Monoclonal antibody
Target
C5 [HSA:727] [KO:K03994]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06513  Complement cascade
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AJ Complement inhibitors
     L04AJ01 Eculizumab
      D03940  Eculizumab (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunological Agents, Other
   Complement Inhibitors
    Eculizumab
     D03940  Eculizumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D03940  Eculizumab (USAN/INN); Eculizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Peptidase inhibitors
   alpha2M family
    C5
     D03940  Eculizumab (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03940
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03940
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03940
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03940
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D03940
Other DBs
CAS: 219685-50-4
PubChem: 47205928
LinkDB

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