Entry
Name
Tadalafil (JAN/USP/INN); Adcirca (TN); Cialis (TN); Zalutia (TN)
Product
Generic
ALYQ (AvKARE) ,
ALYQ (Teva Pharmaceuticals USA) ,
ALYQ (Teva Pharmaceuticals) ,
TADALAFIL (A-S Medication Solutions) ,
TADALAFIL (A-S Medication Solutions) ,
TADALAFIL (A-S Medication Solutions) ,
TADALAFIL (A-S Medication Solutions) ,
TADALAFIL (A-S Medication Solutions) ,
TADALAFIL (A-S Medication Solutions) ,
TADALAFIL (A-S Medication Solutions) ,
TADALAFIL (A-S Medication Solutions) ,
TADALAFIL (ANI Pharmaceuticals) ,
TADALAFIL (Accord Healthcare) ,
TADALAFIL (Advanced Rx of Tennessee) ,
TADALAFIL (Ajanta Pharma USA) ,
TADALAFIL (Alembic Pharmaceuticals Limited) ,
TADALAFIL (Alembic Pharmaceuticals) ,
TADALAFIL (Amneal Pharmaceuticals NY LLC) ,
TADALAFIL (Amneal Pharmaceuticals NY LLC) ,
TADALAFIL (Aphena Pharma Solutions - Tennessee) ,
TADALAFIL (Aphena Pharma Solutions - Tennessee) ,
TADALAFIL (Aphena Pharma Solutions - Tennessee) ,
TADALAFIL (Aphena Pharma Solutions - Tennessee) ,
TADALAFIL (Asclemed USA) ,
TADALAFIL (Asclemed USA) ,
TADALAFIL (Asclemed USA) ,
TADALAFIL (Asclemed USA) ,
TADALAFIL (Aurobindo Pharma Limited) ,
TADALAFIL (Aurobindo Pharma Limited) ,
TADALAFIL (AvKARE) ,
TADALAFIL (AvPAK) ,
TADALAFIL (Bryant Ranch Prepack) ,
TADALAFIL (Bryant Ranch Prepack) ,
TADALAFIL (Bryant Ranch Prepack) ,
TADALAFIL (Bryant Ranch Prepack) ,
TADALAFIL (Bryant Ranch Prepack) ,
TADALAFIL (Bryant Ranch Prepack) ,
TADALAFIL (Bryant Ranch Prepack) ,
TADALAFIL (Bryant Ranch Prepack) ,
TADALAFIL (Burel Pharmaceuticals) ,
TADALAFIL (Camber Pharmaceuticals) ,
TADALAFIL (Camber Pharmaceuticals) ,
TADALAFIL (Cipla USA) ,
TADALAFIL (Cipla USA) ,
TADALAFIL (Coupler LLC) ,
TADALAFIL (Direct_Rx) ,
TADALAFIL (Dr.Reddys Laboratories) ,
TADALAFIL (Dr.Reddys Laboratories) ,
TADALAFIL (FOURRTS (INDIA) LABORATORIES PRIVATE LIMITED) ,
TADALAFIL (Lupin Pharmaceuticals) ,
TADALAFIL (Macleods Pharmaceuticals Limited) ,
TADALAFIL (Macleods Pharmaceuticals Limited) ,
TADALAFIL (NIVAGEN PHARMACEUTICALS) ,
TADALAFIL (NorthStar RxLLC) ,
TADALAFIL (Northwind Pharmaceuticals) ,
TADALAFIL (Northwind Pharmaceuticals) ,
TADALAFIL (Northwind Pharmaceuticals) ,
TADALAFIL (Northwind Pharmaceuticals) ,
TADALAFIL (NuCare Pharmaceuticals) ,
TADALAFIL (NuCare Pharmaceuticals) ,
TADALAFIL (NuCare Pharmaceuticals) ,
TADALAFIL (NuCare Pharmaceuticals) ,
TADALAFIL (NuCare Pharmaceuticals) ,
TADALAFIL (NuCare Pharmaceuticals) ,
TADALAFIL (NuCare Pharmaceuticals) ,
TADALAFIL (NuCare Pharmaceuticals) ,
TADALAFIL (PD-RX Pharmaceuticals) ,
TADALAFIL (PD-Rx Pharmaceuticals) ,
TADALAFIL (PD-Rx Pharmaceuticals) ,
TADALAFIL (PD-Rx Pharmaceuticals) ,
TADALAFIL (PD-Rx Pharmaceuticals) ,
TADALAFIL (PD-Rx Pharmaceuticals) ,
TADALAFIL (Preferred Pharmaceuticals) ,
TADALAFIL (Preferred Pharmaceuticals) ,
TADALAFIL (Preferred Pharmaceuticals) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Proficient Rx LP) ,
TADALAFIL (Qilu Pharmaceutical) ,
TADALAFIL (Quallent Pharmaceuticals Health LLC) ,
TADALAFIL (REMEDYREPACK) ,
TADALAFIL (REMEDYREPACK) ,
TADALAFIL (REMEDYREPACK) ,
TADALAFIL (Solco Healthcare US) ,
TADALAFIL (Solco Healthcare US) ,
TADALAFIL (Sun Pharmaceutical Industries) ,
TADALAFIL (Teva Pharmaceuticals USA) ,
TADALAFIL (Teva Pharmaceuticals) ,
TADALAFIL (Torrent Pharmaceuticals Limited) ,
TADALAFIL (Torrent Pharmaceuticals Limited) ,
TADALAFIL (Unichem Pharmaceuticals (USA)) ,
TADALAFIL (Upsher-Smith Laboratories) ,
TADALAFIL (VKT Pharma Private Limited) ,
TADALAFIL (XLCare Pharmaceuticals) ,
TADALAFIL (Zydus Lifesciences Limited) ,
TADALAFIL (Zydus Pharmaceuticals USA) ,
TADALAFIL (medsource pharmaceuticals)
Formula
C22H19N3O4
Exact mass
389.1376
Mol weight
389.40
Structure
Mol file KCF file DB search
Class
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Remark
Product (mixture): D12486<US > D12963<JP /US >
Efficacy
Antihypertensive, Impotence therapy, Phosphodiesterase V inhibitor
Disease
Pulmonary arterial hypertension [DS:
H01621 ]
Comment
Treatment of male erectile and female sexual dysfunction
Target
Pathway
Metabolism
Enzyme: CYP3A4 [HSA:
1576 ]
Interaction
DDI search
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BE Drugs used in erectile dysfunction
G04BE08 Tadalafil
D02008 Tadalafil (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302 ]
Genitourinary Agents
Benign Prostatic Hypertrophy Agents
Tadalafil
D02008 Tadalafil (JAN/USP/INN)
Respiratory Tract/Pulmonary Agents
Pulmonary Antihypertensives
Phosphodiesterase-5 (PDE5) Inhibitors
Tadalafil
D02008 Tadalafil (JAN/USP/INN)
Sexual Disorder Agents
Sexual Disorder Agents (Male)
Tadalafil
D02008 Tadalafil (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301 ]
2 Agents affecting individual organs
21 Cardiovascular agents
219 Miscellaneous
2190 Miscellaneous
D02008 Tadalafil (JAN/USP/INN)
25 Urogenital and anal organ agents
259 Miscellaneous
2590 Miscellaneous
D02008 Tadalafil (JAN/USP/INN)
Drug groups [BR:br08330 ]
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
D02008 Tadalafil
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D02008 Tadalafil
Target-based classification of drugs [BR:br08310 ]
Enzymes
Hydrolases (EC3)
Phosphodiesterases
PDE5
D02008 Tadalafil (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html ]
New molecular entities and new therapeutic biological products
D02008
New drug approvals in Europe [br08329.html ]
European public assessment reports (EPAR) authorised medicine
D02008
New drug approvals in Japan [br08318.html ]
Drugs with new active ingredients
D02008
New drug approvals in the USA, Europe and Japan [br08328.html ]
Approval dates by FDA, EMA and PMDA
D02008
Drug metabolizing enzymes and transporters [br08309.html ]
Drug metabolizing enzymes
D02008
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 29
1 N1y N 29.4582 -12.6733
2 C1x C 30.1741 -13.7777
3 C5x C 29.5963 -15.0632
4 N1y N 28.2326 -15.0448
5 C1y C 27.4708 -14.1585
6 C5x C 28.0566 -12.6389
7 C1y C 27.6549 -16.4236
8 C8y C 26.2912 -16.4518
9 C1x C 26.1152 -14.1159
10 C8y C 25.5294 -15.3555
11 O5x O 27.2788 -11.5908
12 O5x O 30.4201 -16.2432
13 C8y C 28.4706 -17.5343
14 C8x C 29.8722 -17.4755
15 C8x C 30.6960 -18.6089
16 C8y C 30.0724 -19.9725
17 C8y C 28.6250 -19.9694
18 C8x C 27.8471 -18.8281
19 O2x O 30.5829 -21.1851
20 C1x C 29.5192 -22.1306
21 O2x O 28.3012 -21.3988
22 C1a C 30.0900 -11.4256
23 C8y C 24.1928 -15.8284
24 C8y C 24.2058 -17.2380
25 N4x N 25.5595 -17.6699
26 C8x C 22.9827 -15.1426
27 C8x C 21.7866 -15.8747
28 C8x C 21.8003 -17.2924
29 C8x C 23.0561 -17.9701
BOND 34
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 1
9 5 9 1
10 10 8 2
11 9 10 1
12 6 11 2
13 3 12 2
14 7 13 1 #Down
15 13 14 2
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 13 18 1
21 16 19 1
22 19 20 1
23 20 21 1
24 17 21 1
25 1 22 1
26 10 23 1
27 23 24 1
28 24 25 1
29 25 8 1
30 23 26 2
31 26 27 1
32 27 28 2
33 28 29 1
34 24 29 2