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KEGG   DRUG: Sivelestat sodium
Entry
D01918                      Drug                                   
Name
Sivelestat sodium (USAN);
Sivelestat sodium hydrate (JP18);
Sivelestat sodium for injection (JP18);
Elaspol (TN)
Formula
C20H21N2O7S. 4H2O. Na
Exact mass
528.1390
Mol weight
528.51
Structure
Simcomp
Remark
Therapeutic category: 3999
Chemical structure group: DG01401
Product (DG01401): D01918<JP>
Efficacy
Anti-inflammatory disease, Elastase inhibitor
Comment
Treatment of acute lung injury, Acute respiratory distress syndrome
Target
ELANE [HSA:1991] [KO:K01327]
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D01918  Sivelestat sodium (USAN); Sivelestat sodium hydrate (JP18); Sivelestat sodium for injection (JP18)
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    ELANE
     D01918  Sivelestat sodium (USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01918  Sivelestat sodium hydrate
  D01918  Sivelestat sodium for injection
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01918
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01918
Other DBs
CAS: 201677-61-4
PubChem: 7848980
ChEBI: 32133
LigandBox: D01918
NIKKAJI: J1.606.661C
LinkDB
KCF data

ATOM        35
            1   Z   Na   33.1053  -16.5396 #+
            2   C8y C    23.9651  -17.7179
            3   S4a S    25.1386  -17.0284
            4   C8x C    23.9651  -19.0788
            5   C8x C    22.7856  -17.0284
            6   N1b N    26.3242  -17.7179
            7   C8x C    22.7856  -19.7562
            8   C8x C    21.6123  -17.7179
            9   C8y C    27.5036  -17.0284
            10  C8y C    21.6123  -19.0788
            11  C8x C    27.4915  -15.6673
            12  C8y C    28.6831  -17.7058
            13  O7a O    20.4267  -19.7562
            14  C8x C    28.6710  -14.9838
            15  C8x C    29.8626  -17.0222
            16  C7a C    19.0597  -19.0365
            17  C8x C    29.8567  -15.6614
            18  C1d C    17.7230  -19.8108
            19  C1a C    17.7230  -21.3591
            20  C1a C    16.3863  -19.0365
            21  C5a C    28.6858  -19.0660
            22  O5a O    27.5092  -19.7483
            23  N1b N    29.8651  -19.7438
            24  C1b C    31.0418  -19.0614
            25  C6a C    32.2210  -19.7392
            26  O6a O    33.3977  -19.0567 #-
            27  O6a O    32.1769  -21.0993
            28  O6a O    19.0287  -17.4918
            29  C1a C    16.3777  -20.5762
            30  O3c O    25.1527  -15.6329
            31  O3c O    25.1527  -18.4329
            32  O0  O    37.6599  -19.1799
            33  O0  O    37.6599  -19.1799
            34  O0  O    37.6599  -19.1799
            35  O0  O    37.6599  -19.1799
BOND        31
            1     3   6 1
            2     4   7 2
            3     5   8 1
            4     6   9 1
            5     7  10 1
            6     9  11 1
            7     9  12 2
            8    10  13 1
            9    11  14 2
            10   12  15 1
            11   13  16 1
            12   14  17 1
            13   16  18 1
            14   18  19 1
            15   18  20 1
            16    8  10 2
            17   15  17 2
            18   12  21 1
            19   21  22 2
            20   21  23 1
            21   23  24 1
            22   24  25 1
            23   25  26 1
            24    2   3 1
            25   25  27 2
            26    2   4 1
            27   16  28 2
            28    2   5 2
            29   18  29 1
            30    3  30 2
            31    3  31 2
BRACKET     1    35.5600  -20.0200   35.5600  -18.2700
            1    38.3600  -18.2700   38.3600  -20.0200
            1  4
 ORIGINAL  1   32
 REPEAT    1   33  34  35

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