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KEGG   DRUG: Amikacin sulfate
Entry
D00865                      Drug                                   
Name
Amikacin sulfate (JP18/USP);
Amikin (TN)
Product
ARIKAYCE (Insmed Incorporated)
  Generic
AMIKACIN SULFATE (Fresenius Kabi USA), AMIKACIN SULFATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), AMIKACIN SULFATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), AMIKACIN SULFATE (Hikma Pharmaceuticals USA), AMIKACIN SULFATE (Qilu Pharmaceutical), AMIKACIN SULFATE (Sagent Pharmaceuticals)
Formula
C22H43N5O13. 2H2SO4
Exact mass
781.2205
Mol weight
781.76
Structure
Simcomp
Class
Antibacterial
 DG01447  Aminoglycoside antibiotic
Remark
Therapeutic category: 6123 6169
ATC code: D06AX12 J01GB06 S01AA21
Chemical structure group: DG00403
Product (DG00403): D00865<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Structure map
map07021  Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX12 Amikacin
      D00865  Amikacin sulfate (JP18/USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB06 Amikacin
      D00865  Amikacin sulfate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA21 Amikacin
      D00865  Amikacin sulfate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Amikacin
    D00865  Amikacin sulfate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   612  Acting mainly on gram-negative bacteria
    6123  Amino sugars
     D00865  Amikacin sulfate (JP18/USP)
   616  Acting mainly on acid-fast bacteria
    6169  Others
     D00865  Amikacin sulfate (JP18/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01447  Aminoglycoside antibiotic
   DG00403  Amikacin
    D00865  Amikacin sulfate
Drug classes [BR:br08332]
 Antibacterial
  DG01447  Aminoglycoside antibiotic
   D00865  Amikacin sulfate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    D00865  Amikacin sulfate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00865  Amikacin sulfate
  D00865  Amikacin sulfate injection
  D00865  Amikacin sulfate for injection
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00865
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00865
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00865
Drug groups [BR:br08330]
 Antibacterial
  DG01447  Aminoglycoside antibiotic
   DG00403  Amikacin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    DG00403  Amikacin
Other DBs
CAS: 39831-55-5
PubChem: 7847930
ChEBI: 2638
LigandBox: D00865
NIKKAJI: J268.900F
LinkDB
KCF data

ATOM        50
            1   C1y C    11.5511  -20.1618
            2   C1y C    11.5511  -21.5619
            3   C1y C    12.7637  -22.2620
            4   C1y C    13.9763  -21.5619
            5   C1y C    13.9763  -20.1618
            6   O2x O    12.7637  -19.4617
            7   O2a O    15.2075  -19.4507
            8   C1y C    16.3816  -18.7617
            9   C1y C    17.5991  -19.4531
            10  C1x C    18.8066  -18.7445
            11  C1y C    18.7967  -17.3443
            12  C1y C    17.5792  -16.6529
            13  C1y C    16.3717  -17.3615
            14  O2a O    17.5692  -15.2613
            15  C1y C    18.7786  -14.5516
            16  C1b C    10.3386  -19.4617
            17  O1a O     9.1430  -20.1522
            18  O1a O    10.3386  -22.2620
            19  N1a N    12.7637  -23.6619
            20  O1a O    15.2075  -22.2730
            21  N1b N    17.5392  -20.8614
            22  C5a C    18.7842  -21.5619
            23  C1c C    19.9968  -20.8619
            24  C1b C    21.2093  -21.5619
            25  C1b C    22.4219  -20.8619
            26  N1a N    23.6345  -21.5619
            27  O2x O    19.9874  -15.2381
            28  C1y C    21.1950  -14.5296
            29  C1y C    21.1851  -13.1294
            30  C1y C    19.9763  -12.4429
            31  C1y C    18.7687  -13.1514
            32  C1b C    22.4391  -15.2356
            33  N1a N    22.4492  -16.6613
            34  O1a O    22.3983  -12.4174
            35  O1a O    19.9662  -11.0610
            36  O1a O    17.5502  -12.4594
            37  O5a O    18.7920  -22.9618
            38  O1a O    19.9968  -19.4619
            39  N1a N    19.9707  -16.6553
            40  O1a O    15.1617  -16.6744
            41  S4a S    29.6828  -18.0616
            42  O1d O    29.6828  -19.4617
            43  O1d O    29.6828  -16.6615
            44  O1d O    31.0830  -18.0616
            45  O1d O    28.2827  -18.0616
            46  S4a S    29.6828  -18.0616
            47  O1d O    29.6828  -19.4617
            48  O1d O    29.6828  -16.6615
            49  O1d O    31.0830  -18.0616
            50  O1d O    28.2827  -18.0616
BOND        50
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1 #Down
            8     8   7 1 #Down
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   12  14 1 #Down
            16   15  14 1 #Down
            17    1  16 1 #Up
            18   16  17 1
            19    2  18 1 #Down
            20    3  19 1 #Up
            21    4  20 1 #Down
            22    9  21 1 #Up
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   15  27 1
            29   27  28 1
            30   28  29 1
            31   29  30 1
            32   30  31 1
            33   15  31 1
            34   28  32 1 #Up
            35   32  33 1
            36   29  34 1 #Down
            37   30  35 1 #Up
            38   31  36 1 #Down
            39   22  37 2
            40   23  38 1 #Up
            41   11  39 1 #Up
            42   13  40 1 #Up
            43   41  42 2
            44   41  43 2
            45   41  44 1
            46   41  45 1
            47   46  47 2
            48   46  48 2
            49   46  49 1
            50   46  50 1
BRACKET     1    26.8800  -20.0200   26.8800  -15.8900
            1    32.5500  -15.8900   32.5500  -20.0200
            1  2
 ORIGINAL  1   41  42  43  44  45
 REPEAT    1   46  47  48  49  50

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