| Entry |
|
|---|
| Name |
Phenoxybenzamine hydrochloride (USP);
Dibenzyline (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C18H22ClNO. HCl
|
|---|
| Exact mass |
339.1157
|
|---|
| Mol weight |
340.28
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
|
|---|
| Remark |
| Product (DG00285): | D00507<US> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, alpha-Adrenergic receptor antagonist |
|---|
| Disease |
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C04 PERIPHERAL VASODILATORS
C04A PERIPHERAL VASODILATORS
C04AX Other peripheral vasodilators
C04AX02 Phenoxybenzamine
D00507 Phenoxybenzamine hydrochloride (USP) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Alpha-adrenergic Blocking Agents
Phenoxybenzamine
D00507 Phenoxybenzamine hydrochloride (USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG00285 Phenoxybenzamine
D00507 Phenoxybenzamine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D00507 Phenoxybenzamine hydrochloride (USP) <US>
ADRA2
D00507 Phenoxybenzamine hydrochloride (USP) <US>
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG00285 Phenoxybenzamine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 C8y C 19.0915 -19.7686
2 C1b C 20.3035 -20.4677
3 C8x C 17.8855 -20.4677
4 C8x C 19.0915 -18.3878
5 N1c N 21.5037 -19.7686
6 C8x C 16.6853 -19.7686
7 C8x C 17.8855 -17.6827
8 C1c C 22.6981 -20.4677
9 C1b C 21.5037 -18.3878
10 C8x C 16.6853 -18.3878
11 C1b C 23.9041 -19.7686
12 C1a C 22.6981 -21.8602
13 C1b C 22.7971 -17.9157
14 O2a O 25.1160 -20.4677
15 X Cl 22.7971 -16.5233
16 C8y C 26.5319 -19.6929
17 C8x C 26.4967 -18.3062
18 C8x C 27.7204 -20.4153
19 C8x C 27.7903 -17.6420
20 C8x C 28.9555 -19.7452
21 C8x C 28.9788 -18.3702
22 X Cl 32.5446 -19.2383
BOND 22
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 3 6 2
6 4 7 1
7 5 8 1
8 5 9 1
9 6 10 1
10 8 11 1
11 8 12 1
12 9 13 1
13 11 14 1
14 13 15 1
15 14 16 1
16 16 17 1
17 16 18 2
18 17 19 2
19 18 20 1
20 19 21 1
21 7 10 2
22 20 21 2
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