| Entry |
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| Name |
5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase;
Fma-MT;
fmaD (gene name);
af390-400 (gene name)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:5-dehydro-6-demethoxy-6-hydroxyfumagillol 6-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 5-dehydro-6-demethoxy-6-hydroxyfumagillol = S-adenosyl-L-homocysteine + 5-dehydrofumagillol [RN: R13123]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
5-dehydro-6-demethoxy-6-hydroxyfumagillol [CPD: C22631]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
5-dehydrofumagillol [CPD: C22619]
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| Comment |
The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin.
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| History |
EC 2.1.1.387 created 2022
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| Pathway |
| ec00998 | Biosynthesis of various antibiotics |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K22571 | 5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase |
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| Genes |
| TATV: | 25778502(TrAtP1_003105) |
| TASP: | 36609029(TrAFT101_006815) |
| AFM: | AFUA_8G00390 AFUA_8G00400 |
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| Reference |
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| Authors |
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y |
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| Title |
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.387 |
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| LinkDB |
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