KEGG ENZYME: 2.1.1.316

ENZYME: 2.1.1.316

Entry

EC 2.1.1.316                Enzyme

Name

mitomycin 6-O-methyltransferase;
MmcR;
mitomycin 7-O-methyltransferase (incorrect);
S-adenosyl-L-methionine:7-demethylmitomycin-A 7-O-methyltransferase (incorrect)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:6-demethylmitomycin-A 6-O-methyltransferase

Reaction(IUBMB)

(1) S-adenosyl-L-methionine + 6-demethylmitomycin A = S-adenosyl-L-homocysteine + mitomycin A [RN:R11191];
(2) S-adenosyl-L-methionine + 6-demethylmitomycin B = S-adenosyl-L-homocysteine + mitomycin B [RN:R11192]

Reaction(KEGG)

R11191 R11192

Substrate

S-adenosyl-L-methionine [CPD:C00019];
6-demethylmitomycin A [CPD:C21163];
6-demethylmitomycin B [CPD:C21164]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
mitomycin A [CPD:C21161];
mitomycin B [CPD:C21162]

Comment

The enzyme, characterized from the bacterium Streptomyces lavendulae, is involved in the biosynthesis of the quinone-containing antibiotics mitomycin A and mitomycin B.

History

EC 2.1.1.316 created 2015

Orthology

K21427

mitomycin 6-O-methyltransferase

Reference

1 [PMID:17461583]

Authors

Gruschow S, Chang LC, Mao Y, Sherman DH

Title

Hydroxyquinone O-methylation in mitomycin biosynthesis.

Journal