| Entry |
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| Name |
3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase;
16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase;
NMT;
16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase;
S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 3-hydroxy-16-methoxy-2,3-dihydrotabersonine = S-adenosyl-L-homocysteine + deacetoxyvindoline [RN: R04013]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
3-hydroxy-16-methoxy-2,3-dihydrotabersonine
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
deacetoxyvindoline [CPD: C02673]
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| Comment |
Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle Catharanthus roseus.
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| History |
EC 2.1.1.99 created 1990, modified 2005
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| Pathway |
| ec00901 | Indole alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K21896 | 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase |
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| Reference |
1 |
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| Authors |
De Luca V, Balsevich J, Tyler RT, Eilert U, Panchuk BD, Kurz WGW. |
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| Title |
Biosynthesis of indole alkaloids - developmental regulation of the biosynthetic-pathway from tabersonine to vindoline in Catharanthus roseus. |
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| Journal |
J Plant Physiol 125:147-156 (1986) |
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| Reference |
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| Authors |
De Luca V, Cutler AJ |
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| Title |
Subcellular Localization of Enzymes Involved in Indole Alkaloid Biosynthesis in Catharanthus roseus. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.99 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.99 |
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| LinkDB |
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