#=GF ID SPAR
#=GF AC PF22004.1
#=GF DE Small regulatory polypeptide of amino acid response
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE manual
#=GF GA 27.00 27.00;
#=GF TC 27.40 73.60;
#=GF NC 25.30 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 81514348 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 28024296
#=GF RT mTORC1 and muscle regeneration are regulated by the
#=GF RT LINC00961-encoded SPAR polypeptide.
#=GF RA Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J,
#=GF RA Monteleone E, Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi
#=GF RA PP;
#=GF RL Nature. 2017;541:228-232.
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family represents human Small regulatory polypeptide of
#=GF CC amino acid response (SPAR) and similar sequences from
#=GF CC vertebrates. SPAR interacts with the lysosomal v-ATPase to
#=GF CC negatively regulate the activation of the signalling complex
#=GF CC mTORC1 upon stimulation with amino acids. It also acts as a
#=GF CC regulator of muscle regeneration following injury [1].
#=GF SQ 69
#=GS A0A2K5XNP0_MANLE/16-90 AC A0A2K5XNP0.1
#=GS A0A7N5KP00_AILME/1-78 AC A0A7N5KP00.1
#=GS A0A7F8Q9W0_LEPWE/1-76 AC A0A7F8Q9W0.1
#=GS A0A452C5H8_BALAS/1-75 AC A0A452C5H8.1
#=GS A0A2I2ZDH5_GORGO/16-90 AC A0A2I2ZDH5.1
#=GS A0A8C9QG77_SPEDA/1-73 AC A0A8C9QG77.1
#=GS A0A8C6HKV3_MUSSI/1-75 AC A0A8C6HKV3.1
#=GS A0A8C7BET4_NEOVI/1-77 AC A0A8C7BET4.1
#=GS A0A8W4FJA7_PIG/1-75 AC A0A8W4FJA7.1
#=GS A0A7J8EG66_MOLMO/1-76 AC A0A7J8EG66.1
#=GS A0A8B8XP25_BALMU/1-75 AC A0A8B8XP25.1
#=GS A0A3Q0D5T4_MESAU/1-75 AC A0A3Q0D5T4.1
#=GS A0A8D2DWG4_SCIVU/1-73 AC A0A8D2DWG4.1
#=GS A0A8D2HVV6_UROPR/1-73 AC A0A8D2HVV6.1
#=GS L5M769_MYODS/1-75 AC L5M769.1
#=GS A0A8C4PF08_EQUAS/1-75 AC A0A8C4PF08.1
#=GS A0A2Y9HCF7_NEOSC/1-76 AC A0A2Y9HCF7.1
#=GS A0A452FWL9_CAPHI/1-69 AC A0A452FWL9.1
#=GS A0A6P6H5P1_PUMCO/1-75 AC A0A6P6H5P1.1
#=GS A0A6J3EP25_SAPAP/16-90 AC A0A6J3EP25.1
#=GS SPAR_HUMAN/16-90 AC A0A1B0GVQ0.2
#=GS A0A8C3VXP6_9CETA/1-75 AC A0A8C3VXP6.1
#=GS A0A2J8T0B0_PONAB/1-75 AC A0A2J8T0B0.1
#=GS A0A8D2FDZ4_THEGE/16-90 AC A0A8D2FDZ4.1
#=GS A0A455BMH8_PHYMC/1-75 AC A0A455BMH8.1
#=GS A0A7J8ITP0_ROUAE/1-75 AC A0A7J8ITP0.1
#=GS A0A6P6CRT3_PTEVA/1-75 AC A0A6P6CRT3.1
#=GS A0A8M1FYG8_URSMA/1-78 AC A0A8M1FYG8.1
#=GS A0A452C5N9_BALAS/50-105 AC A0A452C5N9.1
#=GS A0A5F7ZJU8_MACMU/16-90 AC A0A5F7ZJU8.1
#=GS A0A2R8ZMG6_PANPA/16-90 AC A0A2R8ZMG6.1
#=GS A0A7F8KGZ6_DELLE/1-75 AC A0A7F8KGZ6.1
#=GS A0A8C8YVE4_PROSS/16-90 AC A0A8C8YVE4.1
#=GS L5KQ13_PTEAL/1-75 AC L5KQ13.1
#=GS A0A7J7UR99_MYOMY/1-75 AC A0A7J7UR99.1
#=GS A0A8I6AS13_RAT/157-231 AC A0A8I6AS13.1
#=GS A0A7J7W3X6_PIPKU/1-75 AC A0A7J7W3X6.1
#=GS A0A8C9CEK6_PHOSS/1-75 AC A0A8C9CEK6.1
#=GS A0A6J3AHW1_VICPA/1-75 AC A0A6J3AHW1.1
#=GS A0A8C9HQE6_9PRIM/1-75 AC A0A8C9HQE6.1
#=GS A0A2I3TKC1_PANTR/16-90 AC A0A2I3TKC1.1
#=GS A0A2Y9JB54_ENHLU/1-77 AC A0A2Y9JB54.1
#=GS A0A2I3NAI5_PAPAN/1-75 AC A0A2I3NAI5.1
#=GS A0A8U0S7K3_MUSPF/1-77 AC A0A8U0S7K3.1
#=GS A0A5N3X3T2_MUNRE/1-75 AC A0A5N3X3T2.1
#=GS A0A341CWS5_NEOAA/1-75 AC A0A341CWS5.1
#=GS A0A667I4T2_LYNCA/1-75 AC A0A667I4T2.1
#=GS A0A2R8MXK2_CALJA/1-75 AC A0A2R8MXK2.1
#=GS A0A6J3RK55_TURTR/1-75 AC A0A6J3RK55.1
#=GS A0A6J1XRR9_ACIJB/1-75 AC A0A6J1XRR9.1
#=GS A0A8D2FHJ4_THEGE/1-75 AC A0A8D2FHJ4.1
#=GS A0A7E6DFL0_9CHIR/1-75 AC A0A7E6DFL0.1
#=GS A0A8C8XHT6_PANLE/1-75 AC A0A8C8XHT6.1
#=GS A0A2K5L5A5_CERAT/16-90 AC A0A2K5L5A5.1
#=GS A0A2K6JS90_RHIBE/1-75 AC A0A2K6JS90.1
#=GS SPAR_MOUSE/1-75 AC A0A1B0GSZ0.1
#=GS A0A8C9J125_PANTA/1-75 AC A0A8C9J125.1
#=GS A0A2K6NNW9_RHIRO/1-75 AC A0A2K6NNW9.1
#=GS A0A6J0YU17_ODOVR/1-75 AC A0A6J0YU17.1
#=GS A0A2K6B831_MACNE/16-90 AC A0A2K6B831.1
#=GS A0A811ZFZ8_NYCPR/1-75 AC A0A811ZFZ8.1
#=GS A0A485PJE3_LYNPA/1-75 AC A0A485PJE3.1
#=GS A0A2K5HCS8_COLAP/16-90 AC A0A2K5HCS8.1
#=GS A0A3Q7MNQ6_CALUR/1-76 AC A0A3Q7MNQ6.1
#=GS A0A2Y9QM94_TRIMA/1-75 AC A0A2Y9QM94.1
#=GS A0A6P6EIK3_OCTDE/1-75 AC A0A6P6EIK3.1
#=GS A0A3Q7THC3_VULVU/1-75 AC A0A3Q7THC3.1
#=GS A0A452FVV4_CAPHI/14-88 AC A0A452FVV4.1
#=GS A0A3Q1M4Q1_BOVIN/1-75 AC A0A3Q1M4Q1.1
A0A2K5XNP0_MANLE/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHAQP.V...P...SARDFWTFM......
A0A7N5KP00_AILME/1-78 ........METAVIGVVAVLFVATVAITCLLCCFSCDSRAQDPQGGPGHGFTVATFHQEASLFTGPGRHAQP.AvatA...GARDFWTFM......
A0A7F8Q9W0_LEPWE/1-76 ........METAVIGVVAVLFVVTVAITCLLCCFSCDSRTQDPQGGPGRSFTVATFRQEASLFTGPGHHAQP.A...A..aGARDFWTFM......
A0A452C5H8_BALAS/1-75 ........METAVIGVVAVLFVVTVAITCILCCFSCDSRTQDSQGSPRPSFTVATFRQEASLSTGPRHHAQP.V...A...GVRDFWTFM......
A0A2I2ZDH5_GORGO/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPVRHAQP.V...P...SAQDFWTFM......
A0A8C9QG77_SPEDA/1-73 ........MESAVIGVVAVLFVFTVAITCILCCFSYDSKTQDPQGGPGHSFTVATFRQEVSLFSGP--QAQS.M...P...STRDFWNVI......
A0A8C6HKV3_MUSSI/1-75 ........METAVIGMVAVLFVITMAITCILCYFSYDSHTQDPERSSRRSFTVATFHQEASLFTGPALQSRP.L...P...RAQNFWTVV......
A0A8C7BET4_NEOVI/1-77 ........METAVIGVVAVLFVVTVAITCLLCCFSCDSRAQDPQGVPGHSFTVATFRQEASLFTGPGRHAQP.A...Aa.vGARDFWTFM......
A0A8W4FJA7_PIG/1-75 ........METAVIGVVAVLFVVTVAITCVLCCFSCDSRARDPQRGPGHSFTVATFRQEASLFTGPGCHIQP.V...A...GARDFWTFM......
A0A7J8EG66_MOLMO/1-76 ........METAVIGMVAVLFVVTVAITCILCCFSCDSKAQDPQGGPGRSFTVATFHQEASLFTGPGRHAQA.V...A..aGARDFWTFM......
A0A8B8XP25_BALMU/1-75 ........METAVIGMVAVLFVVTVAITCILCCFSCDSRTQDSQGSPRPSFTVATFRQEASLSTGPGHHAQP.V...A...GVRDFWTFM......
A0A3Q0D5T4_MESAU/1-75 ........METAVIGMVAVLLAVTVVITCILCYFSYDSKTSDPEMGPRNSFTVATFHQEASIFTGPGLQSRP.L...P...TARNFCTV-a.....
A0A8D2DWG4_SCIVU/1-73 ........MESAVIGVVAVLFVFTVAITCILCCFSYDSKTQDPQGGPGHSFTVATFRQEASLFTGP--QAQS.V...P...STRDFWTVI......
A0A8D2HVV6_UROPR/1-73 ........MESAVIGVVAVLFVFTVAITCILCCFSYDSKTQDPQGGPGHSFTVATFRQEASLFSGP--QAQS.M...R...STQDFWTVI......
L5M769_MYODS/1-75 ........METAVIGMVGVLFVVTVAITCILCCFSCDSKAPDPQGGPGRSFTVATFHQEASLFTGPARHAQA.V...A...GARDFWTFM......
A0A8C4PF08_EQUAS/1-75 ........METAVIGVVMVLFAVTVVVTCILCCFSCDSRARGPHGGPGRSFTVATFRQEPSLFSGPGHHAQP.V...G...STQDFWTFM......
A0A2Y9HCF7_NEOSC/1-76 ........METAVIGVVAVLFVVTVAITCLLCCFSCDSRTQDPQGGPGRSFTVATFRQEASLFTGPGHHAQL.A..aA...GARDFWTFM......
A0A452FWL9_CAPHI/1-69 ........METAVIGMVAVLFVVTVAITCVLCCFSCDSRSQDPQGAPSPSFTVATFRQEASLFTGPGRHAH-.-...-...---------lpgfar
A0A6P6H5P1_PUMCO/1-75 ........METAVIGVVAVLFVVTVAITCILCCFSCDSRTQDPQGGPGHSFTVATFCQEASFFTGPGHHAQP.V...V...GARDFWTFM......
A0A6J3EP25_SAPAP/16-90 ........METAVIGVVAVLFMVTVTITCVLCCFSCDSRAQDLQGAPGSSFTVATFHREASLFTGPGRHAQP.G...P...SARDFWTFM......
SPAR_HUMAN/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPVRHAQP.V...P...SAQDFWTFM......
A0A8C3VXP6_9CETA/1-75 ........MEMAVIGVVAVLSVVTVAITCVLCCFSCDSRAQDPQRGPGHSFTVATFRQEASLFTGPGRHVQP.V...A...GARDFWTFM......
A0A2J8T0B0_PONAB/1-75 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPVRHAQL.V...P...SAQDFWTFM......
A0A8D2FDZ4_THEGE/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHAQP.V...P...SARDFWTFM......
A0A455BMH8_PHYMC/1-75 ........METAVIGMVAVLFVVTVAITCILCCFSCDSRTPDSQGGPRPSFTVATFHQEASVFTGPGHHAQP.V...A...GVRDFWTFM......
A0A7J8ITP0_ROUAE/1-75 ........METAVIGMVAVLFVVTVAITCVLCCFSCDSRAQDPQGGPGHSFTVATFRREACLFTGPGRHVQP.V...A...GARDFWTFM......
A0A6P6CRT3_PTEVA/1-75 ........METAVIGMVAVLFVVTVAITCVLCCFSCDSRAQDPQEGPGRSFTVATFRREACLFTGPGRHVQP.V...A...GARDFWTFM......
A0A8M1FYG8_URSMA/1-78 ........METAVIGVVAVLFLVTVAITCLLCCFSCDSRALDPQGGPGHSFTVATFHQEASLFTGPGRHAQP.V...AataGARDFWTFM......
A0A452C5N9_BALAS/50-105 scpsrspg---------------------------CDSRTQDSQGSPRPSFTVATFRQEASLSTGPRHHAQP.V...A...GVRDFWTFM......
A0A5F7ZJU8_MACMU/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHAQP.V...P...SARDFWTFM......
A0A2R8ZMG6_PANPA/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRSQDPQGGPGRSFTVATFRQEASLFSGPVRHAQP.V...P...SAQDFWTFM......
A0A7F8KGZ6_DELLE/1-75 ........METAVIGMVAVLFVVTVAISCILCCFSCDSRTQDSQGGLRPSFTVATFRQEASLSTGPGHHVQP.V...A...GVRDFWTFM......
A0A8C8YVE4_PROSS/16-90 ........METAVIGVVVVLFMVTVAITCVLCCFSCDSRTQHPQGGPGRSFTVATFRQEASLFTGPSRHAPP.A...P...SARDFWTFM......
L5KQ13_PTEAL/1-75 ........METAVIGMVAVLFVVTVAITCVLCCFSCDSRAQDPQEGPGRSFTVATFRREACLFTGPGRHVQP.V...A...GARDFWTFM......
A0A7J7UR99_MYOMY/1-75 ........METAVIGMVAVLFVVTVAITCILCCFSCDSKAPDPQGGPGRSFTVATFHQEASLFTGPARHAQA.V...A...GARDFWTFM......
A0A8I6AS13_RAT/157-231 ........METAVIGMVVVLFVITMAITCILCYFSYDSHNQDAESGPRRSFTVATFHQEASLFTGPALQSRP.L...P...RAQNFWTVV......
A0A7J7W3X6_PIPKU/1-75 ........METVVIGMVAVLFVVTVAITCILCCFSCDAKAPDPQAGPGRSFTVATFRQEDSLFTGPGRHGQA.V...A...GARDFWTFM......
A0A8C9CEK6_PHOSS/1-75 ........METAVIGMVAVLFVVTVTISCILCCLSCDSRTQDSQGGPRPSFTVATFRQEASLSTGPGHHVQP.V...A...GVRDFWTFM......
A0A6J3AHW1_VICPA/1-75 ........MESAVIGVVAVLFVVTVAITCVLCCFSCDSRAQDLQGGPGRSFTVATFRQEASLFTGPSCHAQP.V...A...GARDFWTFM......
A0A8C9HQE6_9PRIM/1-75 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHAQP.V...P...SARDFWTFM......
A0A2I3TKC1_PANTR/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRSQDPQGGPGRSFTVATFRQEASLFSGPVRHAQP.V...P...SAQDFWTFM......
A0A2Y9JB54_ENHLU/1-77 ........METAVIGVVAVLFVVTVAITCLLCCFSCDSRAQDPQGGPGHSFTVATFRQEASLFTGPGRHTQP.A...Aa.vGARDFWTFM......
A0A2I3NAI5_PAPAN/1-75 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHVQP.V...P...SARDFWTFM......
A0A8U0S7K3_MUSPF/1-77 ........METAVIGVVAVLFVVTVAITCLLCCFSCDSRAQDPQGGPGHSFTVATFRQEASLFTGPGRHAQP.A...Aa.vGARDFWTFM......
A0A5N3X3T2_MUNRE/1-75 ........MEAAVIGMVAVLFVVTVAITCVLCCFSCDSRGQDPQGAPRPSFTVATFRQEASLFTGPGRHAQP.V...A...GARDFWTFM......
A0A341CWS5_NEOAA/1-75 ........METAVIGMVAVLFVVTVAISCILCCLSCDSRTQDSQGGPRPSFTVATFRQEASLSTGPGHHVQP.V...A...GVRDFWTFM......
A0A667I4T2_LYNCA/1-75 ........METAVIGVVAVLFVVTVAITCILCCFSCDSRTQDPQGGPGHSFTVATFCQEASFFTGPGHHAQP.V...V...GARDFWTFM......
A0A2R8MXK2_CALJA/1-75 ........METAVIGVVAVLFVVTVTITCVLCCFSCDSRAQDLQEGSGSSFTVATFRQEASLFTGPGRHAQP.V...P...SAQDFWTFM......
A0A6J3RK55_TURTR/1-75 ........METAVIGIVAVLFVVTVAITCILCCFSCDSRTQDSQGGPHPSFTVATFRQEASLSTGPGHHVQP.V...A...GVRDFWTFM......
A0A6J1XRR9_ACIJB/1-75 ........METAVIGVVAVLFVVTVAITCILCCFSCDSRTQDPQGGLGHSFTVATFCQEASFFTGPGHHAQP.V...V...GARDFWTFM......
A0A8D2FHJ4_THEGE/1-75 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHAQP.V...P...SARDFWTFM......
A0A7E6DFL0_9CHIR/1-75 ........METAVIGMVAVLFVVTVAITCVLCCFSCDSRAQDPQGGPGHSFTVATFHQEASLFTGPGRHAQP.V...S...GARDFWTFM......
A0A8C8XHT6_PANLE/1-75 ........METAVIGVVAVLFVVTVAITCILCCFSCDSRTQDPQGGPGHSFTVATFCQEASFFTGPGHHAQP.V...V...GARDFWTFM......
A0A2K5L5A5_CERAT/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHAQP.V...P...SARDFWTFM......
A0A2K6JS90_RHIBE/1-75 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHAQP.V...P...SARDFWTFM......
SPAR_MOUSE/1-75 ........METAVIGMVAVLFVITMAITCILCYFSYDSHTQDPERSSRRSFTVATFHQEASLFTGPALQSRP.L...P...RPQNFWTVV......
A0A8C9J125_PANTA/1-75 ........METAVIGVVAVLFVVTVAITCILCCFSCDSRTQDPQGGPGHSFTVATFCQEASFFTGPGHHAQP.V...V...GARDFWTFM......
A0A2K6NNW9_RHIRO/1-75 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEVSLFTGPGRHAQP.V...P...SARDFWTFM......
A0A6J0YU17_ODOVR/1-75 ........MEAAVIGMVAVLFAVTVAITCVLCCFSCDARSQDPQGAPRPSFTVATFHQEASLFTGPGRHAQP.V...A...GARDFWTFM......
A0A2K6B831_MACNE/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHAQP.V...P...SARDFWTFM......
A0A811ZFZ8_NYCPR/1-75 ........METAVIGVVAVLLVVTVAITCLLCCFSCDSRAQDPQGGPGHSFTVATFRKEASLFTGPGHHAQP.T...T...GARDFWTFM......
A0A485PJE3_LYNPA/1-75 ........METAVIGVVAVLFVVTVAITCILCCFSCDSRTQDPQGGPGHSFTVATFCQEASFFTGPGHHAQP.V...V...GARDFWTFM......
A0A2K5HCS8_COLAP/16-90 ........METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPGRHAQP.V...P...SARDFWTFM......
A0A3Q7MNQ6_CALUR/1-76 ........METAVIGMVVVLFVVTVAITCLLCCFSCDSRTQDPQGGPGRSFTVATFHQEASLFTGPGHHAQPpV...A...GARDFWTFM......
A0A2Y9QM94_TRIMA/1-75 ........METAVIGVVAVLFVVTVAITCILCCFSCDPETQDPQGGPGPSFTVATFHQEASLFTGPGHHTQL.A...A...GARDFWTFM......
A0A6P6EIK3_OCTDE/1-75 ........MEILVIGVVAVLLLVTVVITCILCCFSYDSKTQDPQGGPGHSFTVATFRRESSFFTRTESRAQP.L...Q...SSQDFWITM......
A0A3Q7THC3_VULVU/1-75 ........METAVIGVVAVLLVVTVAITCLLCCFSCDSRAQDPQGGPGHSFTVATFRQEASLFTGPGHHAQP.T...T...GARDFWTFM......
A0A452FVV4_CAPHI/14-88 ........METAVIGMVAVLFVVTVAITCVLCCFSCDSRSQDPQGAPSPSFTVATFRQEASLFTGPGRHAQP.V...A...GARDFWTFM......
A0A3Q1M4Q1_BOVIN/1-75 ........METAVIGVVAVLFVVTVAITCVLCCFSCDSRSQDPQGAPSPSFTVATFRKEASLFTGPDHNAQP.V...A...GAWDFWTFM......
#=GC seq_cons ........METAVIGVVAVLFVVTVAITClLCCFSCDSRuQDPQGGPG+SFTVATFRQEASLFTGPG+HAQP.V...s...uARDFWTFM......
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