Research Interests

We are dedicated to solving critical questions in human disease biology by using cutting-edge bioinformatics and genomics technologies, especially cancer. Specially, we integrate computational biology algorithms and molecular experimental technologies to reveal systematical changes and functional factors in disease progression, disease microenvironment and response to drug treatment. Our studies are aiming to impel the development of immunotherapy and targeted therapy. First, we use single-cell sequencing technology to study disease microenvironment, especially the accurate compositions and functions of infiltrated immune cells. Single-cell sequencing is also used to study disease heterogeneity and its impact on disease cell functions and drug sensitivity. Second, we utilize bioinformatics methods to analyze disease multi-omics data, revealing disease subtypes, driver genes and hereditary basis of other pathogens, such as gene fusion, alterations of alleles and disease-specific isoforms. Our study discovers candidate targets for disease diagnosis and therapy. Third, we develop original bioinformatics tools for analysis, integration and visualization of single-cell and other high-throughput disease omics data. We expect to promote the development of disease immunotherapy and targeted therapy through immunogenomics.