A randomized controlled trial involving people with psychosis who hear distressing voices reported that two different forms of AVATAR therapy, an intervention where voice-hearers engage with a digital avatar representing this distressing voice, reported further improvements in voice-related distress at 16 weeks but not at 28 weeks on top of standard of care.

In participants with obesity and chronic kidney disease without diabetes, once-weekly administration of semaglutide 2.4 mg led to a reduction in albuminuria, body weight and systolic blood pressure compared with placebo, with no changes to creatinine or cystatin-C estimated glomerular filtration rate or measured glomerular filtration rate during the 24-week follow-up period.

An analysis of all available Mpox virus sequences, including 10,670 sequences from 65 countries collected between 1958 and 2024 unveils the circulation pattern and spatiotemporal dynamics underlying the spread of the different viral clades.

Trauma and infections increase during war, while routine cancer care is disrupted, but telemedicine, AI chatbots and electronic health records can help.

Single-nucleus and single-cell RNA sequencing plus spatial profiling with four methods of core biopsies from 60 patients with metastatic breast cancer reveal patient-specific gene expression programs of breast cancer metastases that are maintained across time, site of metastasis and spatial profiling method, with spatial phenotypes correlating with microenvironmental features.

A randomized controlled trial involving people with psychosis who hear distressing voices reported that two different forms of AVATAR therapy, an intervention where voice-hearers engage with a digital avatar representing this distressing voice, reported further improvements in voice-related distress at 16 weeks but not at 28 weeks on top of standard of care.

In participants with obesity and chronic kidney disease without diabetes, once-weekly administration of semaglutide 2.4 mg led to a reduction in albuminuria, body weight and systolic blood pressure compared with placebo, with no changes to creatinine or cystatin-C estimated glomerular filtration rate or measured glomerular filtration rate during the 24-week follow-up period.

A precision medicine approach used unsupervised clustering to identify five distinct phenotypic profiles that can better predict risks of cardiometabolic disease compared with those ascertained based on the additive value of body mass index and other biomarkers, and validated these findings across four independent cohorts.

An analysis of all available Mpox virus sequences, including 10,670 sequences from 65 countries collected between 1958 and 2024 unveils the circulation pattern and spatiotemporal dynamics underlying the spread of the different viral clades.

A randomized, sham-controlled, superiority trial of a 10-week course of home-based transcranial direct current stimulation found greater improvements in depressive symptoms with active compared to sham stimulation in major depressive disorder.

Growing momentum to transform the African regulatory landscape should enable 60% of the vaccines needed in Africa to be locally produced by 2040.

Trauma and infections increase during war, while routine cancer care is disrupted, but telemedicine, AI chatbots and electronic health records can help.

Google’s development of MedLM found that risk management processes were an essential tool to protect patient safety.

A large study failed to show a reduction in gastric cancer incidence or mortality when Helicobacter pylori screening was added to standard colon cancer screening.